BCL2L1

Gene Symbol BCL2L1
Entrez Gene 598
Alt Symbol BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS
Species Human
Gene Type protein-coding
Description BCL2-like 1
Other Description apoptosis regulator Bcl-X|bcl-2-like protein 1|protein phosphatase 1, regulatory subunit 52
Swissprots Q92976 Q5CZ89 Q5TE65 E1P5L6 Q07817
Accessions AAB17354 BAA06406 CAT03369 CAT03400 CBX47501 CBX47502 EAW76424 EAW76425 EAW76426 EAW76427 EAW76428 EAW76429 Q07817 AK290968 BAF83657 AY263335 AAP22027 AY263336 AAP22028 AY263337 AAP22029 BC019307 AAH19307 BT007208 AAP35872 BX647525 CR936637 CAI56777 DQ893461 ABM84387 DQ896311 ABM87310 Z23115 CAA80661 Z23116 CAA80662 XM_005260486 XP_005260543 XM_005260487 XP_005260544 XM_011528960 XP_011527262 XM_011528961 XP_011527263 XM_011528962 XP_011527264 XM_011528963 XP_011527265 XM_011528964 XP_011527266 XM_011528965 XP_011527267 XM_011528966 XP_011527268 XR_936599 NM_001191 NP_001182 NM_138578 NP_612815
Function Isoform Bcl-X(S) promotes apoptosis.
Subcellular Location Isoform Bcl-X(L): Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}.
Tissue Specificity Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Top Pathways Apoptosis, Toxoplasmosis, Pancreatic cancer, HTLV-I infection, Amyotrophic lateral sclerosis (ALS)

Bcl-xL (54H6) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 2767 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 54H6
Flow cytometric analysis of SEM (blue) and K-562 (green) cells using Bcl-xL (54H6) Rabbit mAb (Alexa Fluor ® 488 Conjugate) compared to nonspecific Rabbit IgG Isotype Control (Alexa Fluor ® 488 Conjugate) #4340 (red).

Bcl-xL (54H6) Rabbit mAb (PE Conjugate) - 13835 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 54H6
Flow cytometric analysis of SEM cells (blue) and K-562 cells (green) using Bcl-xL (54H6) Rabbit mAb (PE Conjugate).

Bcl-xL (54H6) Rabbit mAb - 2764 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 54H6
Western blot analysis of extracts from Jurkat and HeLa (human), COS (monkey), NIH/3T3 and L929 (mouse), and PC12 and C6 (rat) cells, using Bcl-xL (54H6) Rabbit mAb.

Bcl-xL Antibody - 2762 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat (human), NIH/3T3 (mouse) or C6 (rat) cells, untreated or etoposide-treated (25 µM, Jurkat) or staurosporine-treated (1 µM, NIH/3T3 and C6), using Bcl-xL Antibody.

Bcl-xβ (C-20) - sc-8277 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bcl-xβ (C-20): sc-8277. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic and perinuclear localization.

Bcl-xβ (D-20) - sc-8278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Bcl-xβ (K-15) - sc-8276 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bcl-xβ (K-15): sc-8276. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic and perinuclear localization.

Bcl-xγ (C-19) - sc-8275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bcl-xγ (C-19): sc-8275. Western blot analysis of Bcl-xγ expression in rat spleen tissue extract.

Bcl-x L (H-5) - sc-8392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-x<sub>L</sub> (H-5): sc-8392. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tumor showing cytoplasmic localization.

Bcl-x L (H-62) - sc-7195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Bcl-x<sub>L</sub> expression in BJAB whole cell lysates. Antibodies tested include Bcl-x<sub>L</sub> (H-62): sc-7195 (A) and Bcl-x<sub>L</sub> (H-5): sc-8392 (B).

Bcl-x L (A-20) - sc-7122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bcl-x<sub>L</sub> (A-20): sc-7122. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

Bcl-x L (44) - sc-136207 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Bcl-x<sub>L</sub>(44): sc-136207. Western blot analysis of Bcl-x<sub>L</sub> expression in human endothelial tissue extract.

Bcl-x L (7B2.5) - sc-56021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Bcl-x<sub>L</sub> (7B2.5): sc-56021. Western blot analysis of Bcl-x<sub>L</sub> expression in BJAB (A), SW480 (B) and C6 (C) whole cell lysates.

p-Bcl-x L (Ser 62) - sc-101644 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Bcl-x<sub>L</sub> (Ser 62): sc-101644. Western blot analysis of p-Bcl-x<sub>L</sub> expression in UV-treated 293 (A) and UV-treated MDA-MB-435 (B) whole cell lysates.

Bcl-x S/L (D-3) - sc-271121 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-x<sub>S/L</sub> (D-3): sc-271121. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic staining of glandular cells.

Bcl-x S/L (M-125) - sc-1690 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl-x<sub>S/L</sub> (M-125): sc-1690. Western blot analysis of Bcl-x<sub>L</sub> isoform expression in BJAB whole cell lysate.

Bcl-x S/L (S-18) - sc-634 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl-x<sub>S/L</sub> (S-18): sc-634. Western blot analysis of Bcl-x<sub>L</sub> expression in BJAB (A) and Ramos (B) whole cell lysates.

Bcl-x S/L (L-19) - sc-1041 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl-x<sub>S/L</sub> (L-19): sc-1041. Western blot analysis of Bcl-x isoform expression in Ramos (A) and K-562 (B) whole cell lysates.

Bcl-x S/L (2H12) - sc-23958 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-x<sub>S/L</sub> (2H12): sc-23958. Western blot analysis of Bcl-x<sub>L</sub> expression in BJAB (A) and NAMALWA (B) whole cell lysates.

Bcl-x S/L (4E19) - sc-70417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-x<sub>S/L</sub> (4E19): sc-70417. Western blot analysis of Bcl-x<sub>S/L</sub> expression in BJAB (A) and SW480 (B) whole cell lysates.

Bcl-x S/L (4H33) - sc-70418 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-x<sub>S/L</sub> (4H33): sc-70418. Western blot analysis of Bcl-x<sub>S/L</sub> expression in BJAB (A), SW480 (B) and C6 (C) whole cell lysates.

Anti-Bcl x antibody - ab125288 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab125288, at 1/25 dilution, staining Bcl x in formalin-fixed, paraffin-embedded Human Hodgkin's lymphoma tissue by Immunohistochemistry.

Anti-Bcl x antibody [BX006 + 2H12] - N-terminal - ab201335 from Abcam

Prices $359.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone BX006 + 2H12
Anti-Bcl x antibody [BX006 + 2H12] - N-terminal (ab201335) at 1 µg/ml + Jurkat cell lysate

Anti-Bcl-XL (phospho S62) antibody - ab30655 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded breast carcinoma, using Phospho-Bcl-XL(Ser62) antibody (ab30655). Left: Untreated; Right: Treated with synthesized phosphopeptide. Tested concentration: 10ug/ml.

Anti-Bcl-XL (phospho S62) antibody (Alexa Fluor® 488) - ab20486 from Abcam

Host Rabbit
Clonality Polyclonal
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