PRKRA

Gene Symbol PRKRA
Entrez Gene 8575
Alt Symbol DYT16, HSD14, PACT, RAX
Species Human
Gene Type protein-coding
Description protein kinase, interferon-inducible double stranded RNA dependent activator
Other Description PKR-associated protein X|PKR-associating protein X|interferon-inducible double stranded RNA-dependent protein kinase activator A|interferon-inducible double-stranded RNA-dependent protein kinase activator A|protein activator of the interferon-induced protein kinase|protein kinase, interferon-inducible double stranded RNA-dependent activator|protein kinase, interferon-inducible double-stranded RNA-dependent activator
Swissprots Q8NDK4 Q6X7T5 Q53G24 A8K3I6 O75569
Accessions AAX88882 EAX11034 EAX11035 EAX11036 EAX11037 O75569 AF072860 AAC25672 AF083033 AAD33099 AK092918 AK093360 AK223107 BAD96827 AK290601 BAF83290 AK296019 BAG58789 AL136615 CAB66550 AL833867 CAD38725 AY251164 AAP20061 BC009470 AAH09470 BG827125 BT007243 AAP35907 CR533525 CAG38556 EU831635 ACE87235 EU831719 ACE86553 XM_005246921 XP_005246978 XM_011512063 XP_011510365 XM_011512064 XP_011510366 XM_011512065 XP_011510367 XM_011512066 XP_011510368 NM_001139517 NP_001132989 NM_001139518 NP_001132990 NM_003690 NP_003681
Function Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, perinuclear region. Cytoplasm.

PACT (D9N6J) Rabbit mAb - 13490 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9N6J
Western blot analysis of extracts from various cell lines using PACT (D9N6J) Rabbit mAb.

PACT Antibody - 12277 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

PACT (D-4) - sc-377103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PACT (D-4): sc-377103. Western blot analysis of PACT expression in non-transfected: sc-117752 (A) and mouse PACT transfected: sc-127290 (B) 293T whole cell lysates.

PACT (N-20) - sc-18768 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PACT (N-20): sc-18768. Immunofluorescence staining of methanol-fixed SK-N-SH cells showing cytoplasmic localization.

PACT (H-67) - sc-292629 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PACT (H-67): sc-292629. Western blot analysis of PACT expression in non-transfected 293T: sc-117752 (A), mouse PACT transfected 293T: sc-127290 (B), HeLa (C), PC-12 (D) and SJRH30 (E) whole cell lysates.

PACT (T-18) - sc-32010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PACT (T-18): sc-32010. Western blot analysis of PACT expression in non-transfected: sc-117752 (A) and mouse PACT transfected: sc-127290 (B) 293T whole cell lysates.

PACT (2830C1a) - sc-81569 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PACT (2830C1a): sc-81569 Western Blot analysis of human recombinant PACT fusion protein.

PACT (HL1950) - sc-53523 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-PACT (HL1950): sc-53523. Western blot analysis of phosphorylated PACT expression in HEK293 whole cell lysate.

Anti-PACT (PKR activating protein) / PRKRA antibody - ab31967 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PACT (PKR activating protein) / PRKRA antibody (ab31967) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate with Human PACT (PKR activating protein) / PRKRA peptide (ab30768) at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-PACT (PKR activating protein) / PRKRA antibody - ab186823 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid cancer tissue labelling PACT (PKR activating protein) / PRKRA with ab186823 at 1/200. Magnification: 400x.

Anti-PACT (PKR activating protein) / PRKRA antibody - ab50916 from Abcam

Prices $379.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PACT (PKR activating protein) / PRKRA antibody (ab50916) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-PACT (PKR activating protein) / PRKRA antibody - ab77215 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-PACT (PKR activating protein) / PRKRA antibody (ab77215) at 5 µg/ml + PC12 cell lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilutiondeveloped using the ECL technique

Anti-PACT (PKR activating protein) / PRKRA antibody - ab56444 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
PACT (PKR activating protein) / PRKRA antibody (ab56444) used in immunohistochemistry at 5ug/ml on formalin fixed and paraffin embedded human tonsil tissue.

Anti-PACT (PKR activating protein) / PRKRA antibody - ab82364 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PACT (PKR activating protein) / PRKRA antibody (ab82364) at 1/50 dilution + HL60 cell line lysates at 35 µg

Anti-PACT (PKR activating protein) / PRKRA antibody [1B9-1A7] - ab117704 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1B9-1A7
Human Tonsil, Formalin-Fixed, Paraffin-Embedded tissue, stained with ab117704 at 2.5µg/ml.

Anti-PACT (PKR activating protein) / PRKRA antibody [EPR3224] - ab75749 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3224
All lanes : Anti-PACT (PKR activating protein) / PRKRA antibody [EPR3224] (ab75749) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLane 3 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PRKRA / PACT Antibody (clone 2830C1a) - LS-C342638 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2830C1a
Western blot analysis of immunized recombinant protein, using anti-PRKRA monoclonal antibody.

Anti-PRKRA / PACT Antibody (clone 1B9-1A7) IHC-plus™ - LS-B5437 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1B9-1A7
Anti-PRKRA / PACT antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5437 concentration 2.5 ug/ml.

Anti-PRKRA / PACT Antibody (N-Terminus) IHC-plus™ - LS-B5704 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PRKRA / PACT antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5704 concentration 5 ug/ml.

Anti-PRKRA / PACT Antibody - LS-C75197 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-PRKRA / PACT Antibody (N-Terminus) - LS-C136988 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKRA / PACT Antibody (phospho-Ser246) - LS-C97113 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of anti-Phospho-PRKRA-pS246 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Anti-PRKRA / PACT Antibody (Internal) - LS-C137160 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKRA / PACT Antibody (clone 2830C1a) - LS-C184603 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2830C1a

Anti-PRKRA / PACT Antibody (aa300-350) - LS-C191236 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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