PRKRA

Gene Symbol	PRKRA
Entrez Gene	8575
Alt Symbol	DYT16, HSD14, PACT, RAX
Species	Human
Gene Type	protein-coding
Description	protein kinase, interferon-inducible double stranded RNA dependent activator
Other Description	PKR-associated protein X|PKR-associating protein X|interferon-inducible double stranded RNA-dependent protein kinase activator A|interferon-inducible double-stranded RNA-dependent protein kinase activator A|protein activator of the interferon-induced protein kinase|protein kinase, interferon-inducible double stranded RNA-dependent activator|protein kinase, interferon-inducible double-stranded RNA-dependent activator
Swissprots	Q8NDK4 Q6X7T5 Q53G24 A8K3I6 O75569
Accessions	AAX88882 EAX11034 EAX11035 EAX11036 EAX11037 O75569 AF072860 AAC25672 AF083033 AAD33099 AK092918 AK093360 AK223107 BAD96827 AK290601 BAF83290 AK296019 BAG58789 AL136615 CAB66550 AL833867 CAD38725 AY251164 AAP20061 BC009470 AAH09470 BG827125 BT007243 AAP35907 CR533525 CAG38556 EU831635 ACE87235 EU831719 ACE86553 XM_005246921 XP_005246978 XM_011512063 XP_011510365 XM_011512064 XP_011510366 XM_011512065 XP_011510367 XM_011512066 XP_011510368 NM_001139517 NP_001132989 NM_001139518 NP_001132990 NM_003690 NP_003681
Function	Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, perinuclear region. Cytoplasm.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PACT (PKR activating protein) / PRKRA full length protein - ab132370 from Abcam Category Protein Source Wheat germ Species Human

Human PACT (PKR activating protein) / PRKRA full length protein - ab183223 from Abcam Category Protein Source E. coli Species Human

Human PACT (PKR activating protein) / PRKRA peptide - ab30768 from Abcam Category Peptide

Human PACT (PKR activating protein) / PRKRA protein fragment - ab152895 from Abcam Category Protein Source Wheat germ Species Human

PRKRA / PACT Antibody Blocking Peptide - LS-E14772 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKRA / PACT Antibody Blocking Peptide - LS-E14773 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKRA / PACT Antibody Blocking Peptide - LS-E7432 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKRA / PACT Antibody Blocking Peptide - LS-E9235 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAX / RX Blocking Peptide - LS-E3149 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PACT Partial Recombinant Protein - H00008575-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PACT Recombinant Protein - H00008575-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RAX Peptide - P0395 from Novus Biologicals Category Peptide Species Human

Phospho-PRKRAS246-Antibody-Blocking-peptide - BP3593a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

PRKRA-Antibody-S246-Blocking-Peptide - BP7744b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRKRA Blocking Peptide - 33R-8043 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRKRA Blocking Peptide - 33R-6483 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRKRA / PACT (1-313, His-tag) - AR51595PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

PRKRA / PACT (1-313, His-tag) - AR51595PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

PRKRA / PACT - H00008575-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKRA / PACT - H00008575-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKRA / PACT - H00008575-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKRA / PACT - H00008575-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKRA fusion protein - Ag1214 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PRKRA, GST-tagged - PRKRA-1960H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Interferon-inducible double stranded RNA-dependent protein kin - CSB-YP018717HU CSB-EP018717HU CSB-BP018717HU CSB-MP018717HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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