| Gene Symbol |
PRKRA
|
| Entrez Gene |
8575
|
| Alt Symbol |
DYT16, HSD14, PACT, RAX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, interferon-inducible double stranded RNA dependent activator
|
| Other Description |
PKR-associated protein X|PKR-associating protein X|interferon-inducible double stranded RNA-dependent protein kinase activator A|interferon-inducible double-stranded RNA-dependent protein kinase activator A|protein activator of the interferon-induced protein kinase|protein kinase, interferon-inducible double stranded RNA-dependent activator|protein kinase, interferon-inducible double-stranded RNA-dependent activator
|
| Swissprots |
Q8NDK4 Q6X7T5 Q53G24 A8K3I6 O75569
|
| Accessions |
AAX88882 EAX11034 EAX11035 EAX11036 EAX11037 O75569 AF072860 AAC25672 AF083033 AAD33099 AK092918 AK093360 AK223107 BAD96827 AK290601 BAF83290 AK296019 BAG58789 AL136615 CAB66550 AL833867 CAD38725 AY251164 AAP20061 BC009470 AAH09470 BG827125 BT007243 AAP35907 CR533525 CAG38556 EU831635 ACE87235 EU831719 ACE86553 XM_005246921 XP_005246978 XM_011512063 XP_011510365 XM_011512064 XP_011510366 XM_011512065 XP_011510367 XM_011512066 XP_011510368 NM_001139517 NP_001132989 NM_001139518 NP_001132990 NM_003690 NP_003681
|
| Function |
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, perinuclear region. Cytoplasm.
|