PRKRA

Gene Symbol PRKRA
Entrez Gene 8575
Alt Symbol DYT16, HSD14, PACT, RAX
Species Human
Gene Type protein-coding
Description protein kinase, interferon-inducible double stranded RNA dependent activator
Other Description PKR-associated protein X|PKR-associating protein X|interferon-inducible double stranded RNA-dependent protein kinase activator A|interferon-inducible double-stranded RNA-dependent protein kinase activator A|protein activator of the interferon-induced protein kinase|protein kinase, interferon-inducible double stranded RNA-dependent activator|protein kinase, interferon-inducible double-stranded RNA-dependent activator
Swissprots Q8NDK4 Q6X7T5 Q53G24 A8K3I6 O75569
Accessions AAX88882 EAX11034 EAX11035 EAX11036 EAX11037 O75569 AF072860 AAC25672 AF083033 AAD33099 AK092918 AK093360 AK223107 BAD96827 AK290601 BAF83290 AK296019 BAG58789 AL136615 CAB66550 AL833867 CAD38725 AY251164 AAP20061 BC009470 AAH09470 BG827125 BT007243 AAP35907 CR533525 CAG38556 EU831635 ACE87235 EU831719 ACE86553 XM_005246921 XP_005246978 XM_011512063 XP_011510365 XM_011512064 XP_011510366 XM_011512065 XP_011510367 XM_011512066 XP_011510368 NM_001139517 NP_001132989 NM_001139518 NP_001132990 NM_003690 NP_003681
Function Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, perinuclear region. Cytoplasm.

PACT CRISPR/Cas9 KO Plasmid (h) - sc-402533 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACT HDR Plasmid (h) - sc-402533-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACT Double Nickase Plasmid (h) - sc-402533-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACT Double Nickase Plasmid (h2) - sc-402533-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACT CRISPR Activation Plasmid (h) - sc-402533-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACT CRISPR Activation Plasmid (h2) - sc-402533-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACT Lentiviral Activation Particles (h) - sc-402533-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACT Lentiviral Activation Particles (h2) - sc-402533-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACT siRNA (h) - sc-36175 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACT shRNA Plasmid (h) - sc-36175-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACT shRNA (h) Lentiviral Particles - sc-36175-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU145131 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17429 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

PRKRA siRNA (Human) - CRH5642 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PACT RNAi - H00008575-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PRKRA (NM_003690.4) - SHH382984 from Creative biogene

Category siRNA
Species Reactivities Human

Human PRKRA siRNA - orb266144 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PRKRA shRNA Plasmid (Human) - CHH5642 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PRKRA miRNA 3'UTR clone - MiUTR3H-05956 from Creative biogene

Species Reactivities Human

PRKRA miRNA 3'UTR clone - MiUTR3H-05957 from Creative biogene

Species Reactivities Human

PRKRA miRNA 3'UTR clone - MiUTR3H-05958 from Creative biogene

Species Reactivities Human
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