CHFR

Gene Symbol	CHFR
Entrez Gene	55743
Alt Symbol	RNF116, RNF196
Species	Human
Gene Type	protein-coding
Description	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase CHFR|RING finger protein 196
Swissprots	Q9NVD5 Q9NRT4 B4DZ77 B4E2L6 Q9NT32 Q96SL3 Q96EP1 A6NEN5
Accessions	EAW54809 EAW54810 EAW54811 EAW54812 EAW54813 EAW54814 EAW54815 Q96EP1 AF170724 AAF91084 AK001658 BAA91817 AK027687 BAB55297 AK054917 AK090948 AK097671 BAG53509 AK302785 BAG63989 AK304333 BAG65178 AL137561 CAB70812 BC012072 AAH12072 BP313700 DQ599878 DQ892232 ABM83158 DQ895433 ABM86359 NM_001161344 NP_001154816 NM_001161345 NP_001154817 NM_001161346 NP_001154818 NM_001161347 NP_001154819 NM_018223 NP_060693
Function	E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. {
Subcellular Location	Nucleus, PML body {ECO:0000269|PubMed:11912157, ECO:0000269|PubMed:15467728, ECO:0000269|PubMed:18172500}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10935642}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHFR overexpression lysate - LY413203 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

CHFR overexpression lysate - LY431493 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CHFR overexpression lysate - LY431554 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CHFR Overexpression Lysate (Native) - NBP2-10156 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human CHFR Knockdown Stable Cell Line - CSC-DC003085 from Creative biogene Category Cell Line Species Human

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