| Gene Symbol | CHFR |
|---|---|
| Entrez Gene | 55743 |
| Alt Symbol | RNF116, RNF196 |
| Species | Human |
| Gene Type | protein-coding |
| Description | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase |
| Other Description | E3 ubiquitin-protein ligase CHFR|RING finger protein 196 |
| Swissprots | Q9NVD5 Q9NRT4 B4DZ77 B4E2L6 Q9NT32 Q96SL3 Q96EP1 A6NEN5 |
| Accessions | EAW54809 EAW54810 EAW54811 EAW54812 EAW54813 EAW54814 EAW54815 Q96EP1 AF170724 AAF91084 AK001658 BAA91817 AK027687 BAB55297 AK054917 AK090948 AK097671 BAG53509 AK302785 BAG63989 AK304333 BAG65178 AL137561 CAB70812 BC012072 AAH12072 BP313700 DQ599878 DQ892232 ABM83158 DQ895433 ABM86359 NM_001161344 NP_001154816 NM_001161345 NP_001154817 NM_001161346 NP_001154818 NM_001161347 NP_001154819 NM_018223 NP_060693 |
| Function | E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. { |
| Subcellular Location | Nucleus, PML body {ECO:0000269|PubMed:11912157, ECO:0000269|PubMed:15467728, ECO:0000269|PubMed:18172500}. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10935642}. |
Human CHFR cDNA clone(NM_001161345.1) - CDFH003587 from Creative Biomart
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Human CHFR cDNA clone(NM_001161346.1) - CDFH003588 from Creative Biomart
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Human CHFR cDNA clone(NM_001161344.1) - CDFH003589 from Creative Biomart
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Human CHFR cDNA clone(NM_001161347.1) - CDFH003590 from Creative Biomart
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Human CHFR ORF Clone(NM_001161344.1) - CDCL158723 from Creative Biomart
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Human CHFR ORF Clone(NM_001161344.1) - CDCL158724 from Creative Biomart
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Human CHFR ORF Clone(NM_001161344.1) - CDCR354004 from Creative Biomart
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Human CHFR ORF Clone(NM_001161345.1) - CDCR354005 from Creative Biomart
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Human CHFR ORF Clone(NM_001161345.1) - CDCR354006 from Creative Biomart
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Human CHFR ORF Clone(NM_001161346.1) - CDCR354007 from Creative Biomart
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Human CHFR ORF Clone(NM_001161344.1) - CDCR354008 from Creative Biomart
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Human CHFR ORF Clone(NM_001161347.1) - CDCR354009 from Creative Biomart
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Human CHFR ORF Clone(NM_001161347.1) - CDCR354010 from Creative Biomart
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Human CHFR ORF Clone(NM_001161346.1) - CDCR354014 from Creative Biomart
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Human CHFR ORF Clone(NM_001161344.1) - CDCR354004 from Creative biogene
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Human CHFR ORF clone (NM_001161345.1) - CDCR046660 from Creative biogene
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Human CHFR ORF clone (NM_001161346.1) - CDCR046662 from Creative biogene
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Human CHFR ORF clone (NM_001161347.1) - CDCR046664 from Creative biogene
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Human CHFR cDNA Clone(NM_001161345.1) - CDFH003587 from Creative biogene
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Human CHFR cDNA Clone(NM_001161346.1) - CDFH003588 from Creative biogene
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Human CHFR cDNA Clone(NM_001161344.1) - CDFH003589 from Creative biogene
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Human CHFR cDNA Clone(NM_001161347.1) - CDFH003590 from Creative biogene
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