| Gene Symbol |
TUB
|
| Entrez Gene |
7275
|
| Alt Symbol |
RDOB, rd5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tubby bipartite transcription factor
|
| Other Description |
tubby homolog|tubby homologue|tubby protein homolog
|
| Swissprots |
P50607 Q6B007 O00293 D3DQU4
|
| Accessions |
CAC14586 CAC39298 EAW68632 EAW68633 EAW68634 P50607 AB209618 BAD92855 AK293528 BAG57010 BC036400 BC075031 AAH75031 BC075032 AAH75032 BM992151 EU446711 ABZ92240 U54644 AAB53494 U82467 AAB53699 XM_005253109 XP_005253166 XM_011520344 XP_011518646 NM_003320 NP_003311 NM_177972 NP_813977
|
| Function |
Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:19837063}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.
|