TUB

Gene Symbol TUB
Entrez Gene 7275
Alt Symbol RDOB, rd5
Species Human
Gene Type protein-coding
Description tubby bipartite transcription factor
Other Description tubby homolog|tubby homologue|tubby protein homolog
Swissprots P50607 Q6B007 O00293 D3DQU4
Accessions CAC14586 CAC39298 EAW68632 EAW68633 EAW68634 P50607 AB209618 BAD92855 AK293528 BAG57010 BC036400 BC075031 AAH75031 BC075032 AAH75032 BM992151 EU446711 ABZ92240 U54644 AAB53494 U82467 AAB53699 XM_005253109 XP_005253166 XM_011520344 XP_011518646 NM_003320 NP_003311 NM_177972 NP_813977
Function Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:19837063}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.

Tub (M-19) - sc-1959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tub (M-19): sc-1959. Western blot analysis of Tub expression in TK-1 whole cell lysate.

Tub (T-19) - sc-1960 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tub (T-19): sc-1960. Western blot analysis of Tub expression in rat brain (A) and mouse brain (B) extracts.

Tub (H-145) - sc-50370 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Tub (H-145): sc-50370. Western blot analysis of Tub expression in mouse uterus (A) and mouse cerebellum (B) tissue extracts.

Tub (40) - sc-136112 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Tub (40): sc-136112. Western blot analysis of Tub expression in mouse cerebrum tissue extract.

Anti-TUB 1 antibody - ab155201 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TUB 1 antibody (ab155201) at 1/1000 dilutionLane 1 : NT2D1 whole cell lysateLane 2 : PC3 whole cell lysateLane 3 : U87-MG whole cell lysateLane 4 : SK-N-SH whole cell lysateLysates/proteins at 30 µg per lane.

Anti-TUB 1 antibody [EPR8241] - ab131034 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8241
All lanes : Anti-TUB 1 antibody [EPR8241] (ab131034) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : Saos-2 cell lysateLane 3 : C6 cell lysateLane 4 : L6 cell lysateLane 5 : Neuro-2a cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Tubby antibody - ab46943 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Tubby antibody (ab46943) at 1 µg/mlLane 1 : Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188)Lane 2 : Brain (Mouse) Tissue LysateLane 3 : Testis (Mouse) Tissue Lysate - normal tissueLane 4 : Spinal Cord (Mouse) Tissue LysateLane 5 : Brain (Rat) Tissue Lysate - normal tissueLane 6 : Rat Dorsal Root GanglionLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Tubby antibody - ab82689 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Tubby antibody (ab82689) at 1 µg/ml + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TUB / Tubby Antibody (N-Terminus) - LS-C18211 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TUB / Tubby Antibody (N-Terminus) - LS-C18213 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TUB / Tubby Antibody (N-Terminus) - LS-C18215 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TUB / Tubby Antibody (N-Terminus) - LS-C18214 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TUB / Tubby Antibody (N-Terminus) - LS-C18216 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TUB / Tubby Antibody (aa160-421) - LS-C89833 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TUB / Tubby Antibody (N-Terminus) - LS-C82000 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-TUB / Tubby Antibody (aa160-421) - LS-C2922 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of tub-1 (GFP complex) using LS-C2922. Tub-1 (nr2004) was used as a negative control.

Anti-TUB / Tubby Antibody (N-Terminus, clone EPR8241) - LS-C154519 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8241
IHC of paraffin-embedded human astrocytoma tissue using anti-TUB antibody.

Anti-TUB / Tubby Antibody (aa144-193) IHC-plus™ - LS-B6532 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TUB antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6532 concentration 5 ug/ml.

Tubby Antibody - NBP2-20758 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Tubby Antibody [NBP2-20758] - Sample (30 ug of whole cell lysate) A: NT2D1 B: PC-3 C: U87-MG D: SK-N-SH 7. 5% SDS PAGE gel, diluted at 1:1000.

Tubby Antibody - H00007275-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

TSH beta Antibody (TSB4) - NB110-8279 from Novus Biologicals

Prices $199.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TSB4

Anti-TUB antibody produced in rabbit - SAB2702101 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TUB: <B>Cat. No. SAB2702101</B>: Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using Tub antibody at a 1:500 dilution.

Anti-TUB (ab1) antibody produced in rabbit - SAB2102601 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TUB (ab1): <B>Cat. No.SAB2102601</B>: TUB in 293T cell lysate with TUB antibody at 1.0 μg/mL.

Anti-TUB antibody produced in rabbit - HPA017997 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TUB: <B>Cat. No. HPA017997</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

Anti-TUB (ab2) antibody produced in rabbit - SAB2102602 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TUB (ab2): <B>Cat. No. SAB2102602</B>: Immunohistochemistry of TUB in Brain,cortex tissue with TUB antibody at 4-8 μg/mL.
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