| Gene Symbol | PTPN14 |
|---|---|
| Entrez Gene | 5784 |
| Alt Symbol | PEZ, PTP36 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, non-receptor type 14 |
| Other Description | cytoskeletal-associated protein tyrosine phosphatase|protein-tyrosine phosphatase pez|tyrosine-protein phosphatase non-receptor type 14 |
| Swissprots | Q5VSI0 Q15678 |
| Accessions | ADN23589 EAW93351 Q15678 AF086517 AK056963 AK090596 AK291641 BAF84330 AK298120 BAG60402 AW192897 BC017300 AAH17300 BC101754 AAI01755 BC104803 AAI04804 BX538306 DA738908 HG493205 HQ116786 ADN23590 X82676 CAA57993 XR_247032 NM_005401 NP_005392 |
| Function | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell- matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial- mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane. |
| Tissue Specificity | Ubiquitous. |
PTPN14 293 Cell Lysate - 408102 from ABBIOTEC
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PTPN14 Over-expression Lysate Product - GWB-CE328C from Genway Biotech
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Panoply™ Human PTPN14 Knockdown Stable Cell Line - CSC-DC012698 from Creative biogene
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