PTPN14

Gene Symbol PTPN14
Entrez Gene 5784
Alt Symbol PEZ, PTP36
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 14
Other Description cytoskeletal-associated protein tyrosine phosphatase|protein-tyrosine phosphatase pez|tyrosine-protein phosphatase non-receptor type 14
Swissprots Q5VSI0 Q15678
Accessions ADN23589 EAW93351 Q15678 AF086517 AK056963 AK090596 AK291641 BAF84330 AK298120 BAG60402 AW192897 BC017300 AAH17300 BC101754 AAI01755 BC104803 AAI04804 BX538306 DA738908 HG493205 HQ116786 ADN23590 X82676 CAA57993 XR_247032 NM_005401 NP_005392
Function Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell- matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial- mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
Tissue Specificity Ubiquitous.

Pez CRISPR/Cas9 KO Plasmid (h) - sc-402896 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pez HDR Plasmid (h) - sc-402896-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pez Double Nickase Plasmid (h) - sc-402896-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pez Double Nickase Plasmid (h2) - sc-402896-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pez CRISPR Activation Plasmid (h) - sc-402896-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pez CRISPR Activation Plasmid (h2) - sc-402896-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pez Lentiviral Activation Particles (h) - sc-402896-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pez Lentiviral Activation Particles (h2) - sc-402896-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pez siRNA (h) - sc-62777 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pez shRNA Plasmid (h) - sc-62777-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pez shRNA (h) Lentiviral Particles - sc-62777-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTPN14/PTPD2 RNAi - H00005784-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU054171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0736 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0738 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0737 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN2286 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2286 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02211 from Sigma-Aldrich

Category miRNA

PTPN14 siRNA (Human) - CRH3907 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human PTPN14 siRNA - orb264409 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PTPN14 shRNA Plasmid (Human) - CHH3907 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PTPN14 miRNA 3'UTR clone - MiUTR3H-05723 from Creative biogene

Species Reactivities Human
Search more