Atg12

Gene Symbol Atg12
Entrez Gene 67526
Alt Symbol 4931423H11Rik, A330058M13Rik, Apg12l, Atg12l
Species Mouse
Gene Type protein-coding
Description autophagy related 12
Other Description autophagy-related 12|autophagy-related protein 12|ubiquitin-like protein ATG12
Swissprots Q9CQY1 Q3TKE5 Q9D7Y5
Accessions EDL09966 EDL09967 Q9CQY1 AB066216 BAB62092 AK005405 BAB24005 AK008698 BAB25839 AK016474 BAB30256 AK039278 AK039546 AK080409 AK088255 AK167027 BAE39200 AK177781 AK177910 AK196572 AK198454 AK206569 AK208391 AK214439 AK218629 AV295996 BB853539 BC070470 AAH70470 XM_006526187 XP_006526250 NM_026217 NP_080493
Function Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269|PubMed:11266458, ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:20723759}.
Subcellular Location Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. {ECO:0000250}.
Tissue Specificity Ubiquitous.
Top Pathways RIG-I-like receptor signaling pathway, Regulation of autophagy

Ubiquitin-like protein ATG12, Atg12, Mouse, ELISA Kit - E2478m from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

ATG12 autophagy related 12 homolog (S. cerevisiae) , ELISA Kit - MBS9341311 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Autophagy Related Protein 12 (ATG12) - SEL224Mu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 13.1pg/mL.
Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA's were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

Mouse Atg12 ELISA Kit - E045038 from Biobool

Category ELISA Kit

ATG12 ELISA Kit (Mouse) (OKEH03507) - OKEH03507 from Aviva Systems Biology

Category ELISA Kit
Prices $425.00
Sizes 96 wells
Sensitivity 39 pg/mL
Range 78 - 5,000 pg/mL

Mouse Ubiquitin-like protein ATG12 ELISA Kit - EK4520 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Sensitivity less than 0.054ng/mL
Range 1.56-100 ng/mL

Ubiquitin-like protein ATG12, ELISA Kit - MBS288850 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin-like protein ATG12, ELISA Kit - MBS9428346 from MyBioSource

Category ELISA Kit
Prices $555.00
Sizes 96 tests
Range 78-5000 pg/mL
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