Atg12

Gene Symbol Atg12
Entrez Gene 67526
Alt Symbol 4931423H11Rik, A330058M13Rik, Apg12l, Atg12l
Species Mouse
Gene Type protein-coding
Description autophagy related 12
Other Description autophagy-related 12|autophagy-related protein 12|ubiquitin-like protein ATG12
Swissprots Q9CQY1 Q3TKE5 Q9D7Y5
Accessions EDL09966 EDL09967 Q9CQY1 AB066216 BAB62092 AK005405 BAB24005 AK008698 BAB25839 AK016474 BAB30256 AK039278 AK039546 AK080409 AK088255 AK167027 BAE39200 AK177781 AK177910 AK196572 AK198454 AK206569 AK208391 AK214439 AK218629 AV295996 BB853539 BC070470 AAH70470 XM_006526187 XP_006526250 NM_026217 NP_080493
Function Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269|PubMed:11266458, ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:20723759}.
Subcellular Location Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. {ECO:0000250}.
Tissue Specificity Ubiquitous.
Top Pathways RIG-I-like receptor signaling pathway, Regulation of autophagy

Atg12 CRISPR/Cas9 KO Plasmid (m) - sc-426609 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Atg12 HDR Plasmid (m) - sc-426609-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Atg12 Double Nickase Plasmid (m) - sc-426609-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Atg12 Double Nickase Plasmid (m2) - sc-426609-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Atg12 CRISPR Activation Plasmid (m) - sc-426609-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Atg12 CRISPR Activation Plasmid (m2) - sc-426609-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Atg12 Lentiviral Activation Particles (m) - sc-426609-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Atg12 Lentiviral Activation Particles (m2) - sc-426609-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Atg12 siRNA (m) - sc-72579 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Atg12 shRNA Plasmid (m) - sc-72579-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Atg12 shRNA (m) Lentiviral Particles - sc-72579-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU072781 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN27145 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27145 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ATG12 siRNA (Mouse) - CRM7221 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ATG12 - MBS8201201 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse ATG12 (NM_026217.3) - SHH242030 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Atg12(NM_026217.3) - SHG079679 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse ATG12 siRNA - orb286697 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ATG12 shRNA Plasmid (Mouse) - CHM7221 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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