| Gene Symbol | Atg12 |
|---|---|
| Entrez Gene | 67526 |
| Alt Symbol | 4931423H11Rik, A330058M13Rik, Apg12l, Atg12l |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | autophagy related 12 |
| Other Description | autophagy-related 12|autophagy-related protein 12|ubiquitin-like protein ATG12 |
| Swissprots | Q9CQY1 Q3TKE5 Q9D7Y5 |
| Accessions | EDL09966 EDL09967 Q9CQY1 AB066216 BAB62092 AK005405 BAB24005 AK008698 BAB25839 AK016474 BAB30256 AK039278 AK039546 AK080409 AK088255 AK167027 BAE39200 AK177781 AK177910 AK196572 AK198454 AK206569 AK208391 AK214439 AK218629 AV295996 BB853539 BC070470 AAH70470 XM_006526187 XP_006526250 NM_026217 NP_080493 |
| Function | Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269|PubMed:11266458, ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:20723759}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | RIG-I-like receptor signaling pathway, Regulation of autophagy |