POLR3H

Gene Symbol	POLR3H
Entrez Gene	171568
Alt Symbol	RPC22.9, RPC8
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
Other Description	DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide|DNA-directed RNA polymerase III subunit H|DNA-directed RNA polymerase III subunit RPC8|RNA nucleotidyltransferase (DNA-directed)|RNA polymerase III subunit C8
Swissprots	Q96AE3 Q9Y535 Q9BY95 Q5M7Y8 B0QYH9
Accessions	EAW60437 EAW60438 EAW60439 EAW60440 EAW60441 Q9Y535 AB051452 BAB33335 AK000365 AK026524 AK129663 BAC85211 AY092087 AAM18217 BC017248 AAH17248 BC088367 AAH88367 BI754673 BM681267 BM701572 BU173504 BU584298 BU928882 BX331353 BX367405 CB126821 CR456459 CAG30345 CU013009 CAK54440 CU013297 CAK54739 DA238361 DA449644 DA504810 GQ129271 ACT64405 GQ129272 ACT64406 XM_011529993 XP_011528295 XR_244356 NM_001018051 NM_001018050 NP_001018060 NM_001018052 NP_001018062 NM_001282884 NP_001269813 NM_001282885 NP_001269814 NM_138338 NP_612211
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

POLR3H overexpression lysate - LY422706 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

POLR3H 293 Cell Lysate - 404708 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

POLR3H 293 Cell Lysate - 409777 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

POLR3H Overexpression Lysate (Native) - NBL1-14595 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

POLR3H Overexpression Lysate (Native) - NBL1-14596 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

POLR3H Overexpression Lysate (Native) - NBP2-08674 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

POLR3H Overexpression Lysate (Native) - NBP2-09161 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

POLR3H Over-expression Lysate Product - GWB-B99887 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

POLR3H Over-expression Lysate Product - GWB-67DBA2 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human POLR3H Knockdown Stable Cell Line - CSC-DC012112 from Creative biogene Category Cell Line Species Human

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