Gene Symbol | POLR3H |
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Entrez Gene | 171568 |
Alt Symbol | RPC22.9, RPC8 |
Species | Human |
Gene Type | protein-coding |
Description | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) |
Other Description | DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide|DNA-directed RNA polymerase III subunit H|DNA-directed RNA polymerase III subunit RPC8|RNA nucleotidyltransferase (DNA-directed)|RNA polymerase III subunit C8 |
Swissprots | Q96AE3 Q9Y535 Q9BY95 Q5M7Y8 B0QYH9 |
Accessions | EAW60437 EAW60438 EAW60439 EAW60440 EAW60441 Q9Y535 AB051452 BAB33335 AK000365 AK026524 AK129663 BAC85211 AY092087 AAM18217 BC017248 AAH17248 BC088367 AAH88367 BI754673 BM681267 BM701572 BU173504 BU584298 BU928882 BX331353 BX367405 CB126821 CR456459 CAG30345 CU013009 CAK54440 CU013297 CAK54739 DA238361 DA449644 DA504810 GQ129271 ACT64405 GQ129272 ACT64406 XM_011529993 XP_011528295 XR_244356 NM_001018051 NM_001018050 NP_001018060 NM_001018052 NP_001018062 NM_001282884 NP_001269813 NM_001282885 NP_001269814 NM_138338 NP_612211 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Top Pathways | Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |
Human POLR3H full length protein - ab134603 from Abcam
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POLR3H Antibody Blocking Peptide - LS-E7653 from LifeSpan Bioscience
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POLR3H Antibody Blocking Peptide - LS-E17551 from LifeSpan Bioscience
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POLR3H Recombinant Protein - H00171568-P01 from Novus Biologicals
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Recombinant Human POLR3H Protein - NBP2-23351 from Novus Biologicals
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RPC8-Antibody-N-term-Blocking-Peptide - BP4936a from Abgent, a WuXi AppTec company
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Human POLR3H protein - orb169055 from Biorbyt
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POLR3H Blocking Peptide - 33R-1242 from Fitzgerald
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POLR3H protein (His tag) - 80R-2507 from Fitzgerald
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POLR3H (1-204, His-tag) - AR50579PU-N from Acris Antibodies
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POLR3H (1-204, His-tag) - AR50579PU-S from Acris Antibodies
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POLR3H - H00171568-P01-10 from Acris Antibodies
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POLR3H - H00171568-P01-25 from Acris Antibodies
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POLR3H, 1-204aa, Human, His tag, E.coli - 01-P1755 from ARP American Research Products
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POLR3H fusion protein - ag9624 from Proteintech Group
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POLR3H fusion protein - ag9639 from Proteintech Group
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POLR3H, 1-204aa, Recombinant Protein - GWB-P0283J from Genway Biotech
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Recombinant Human Polymerase (RNA) III (DNA Sirected) Polypeptide H (22.9kD), His-tagged - POLR3H-7187H from Creative Biomart
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Recombinant Human DNA-directed RNA polymerase III subunit RPC8(POLR3H) - CSB-YP897557HU CSB-EP897557HU CSB-BP897557HU CSB-MP897557HU from Cusabio
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POLR3H, 1-204aa, Human, His tag, E.coli - ATGP1755 from ATGen
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POLR3H (transcript variant 3) - TP310633 from Acris Antibodies
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POLR3H, Recombinant Protein - MBS204467 from MyBioSource
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Polymerase III, Recombinant Protein - MBS145521 from MyBioSource
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POLR3H Recombinant Protein Antigen - NBP2-13787PEP from Novus Biologicals
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POLR3H Blocking Peptide - abx162142 from Abbexa
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