POLR3H

Gene Symbol POLR3H
Entrez Gene 171568
Alt Symbol RPC22.9, RPC8
Species Human
Gene Type protein-coding
Description polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
Other Description DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide|DNA-directed RNA polymerase III subunit H|DNA-directed RNA polymerase III subunit RPC8|RNA nucleotidyltransferase (DNA-directed)|RNA polymerase III subunit C8
Swissprots Q96AE3 Q9Y535 Q9BY95 Q5M7Y8 B0QYH9
Accessions EAW60437 EAW60438 EAW60439 EAW60440 EAW60441 Q9Y535 AB051452 BAB33335 AK000365 AK026524 AK129663 BAC85211 AY092087 AAM18217 BC017248 AAH17248 BC088367 AAH88367 BI754673 BM681267 BM701572 BU173504 BU584298 BU928882 BX331353 BX367405 CB126821 CR456459 CAG30345 CU013009 CAK54440 CU013297 CAK54739 DA238361 DA449644 DA504810 GQ129271 ACT64405 GQ129272 ACT64406 XM_011529993 XP_011528295 XR_244356 NM_001018051 NM_001018050 NP_001018060 NM_001018052 NP_001018062 NM_001282884 NP_001269813 NM_001282885 NP_001269814 NM_138338 NP_612211
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Top Pathways Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

POLR3H (D-19) - sc-86797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
POLR3H (D-19): sc-86797. Western blot analysis of POLR3H expression in mouse liver tissue extract.

POLR3H (N-14) - sc-86798 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-POLR3H antibody - ab104193 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-POLR3H antibody (ab104193) at 1/100 dilution + Mouse testis tissue lysates at 35 µg

Anti-POLR3H antibody - ab75065 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-POLR3H antibody (ab75065) at 1/500 dilutionLane 1 : extracts from K562 cellsLane 2 : extracts from K562 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-POLR3H Antibody (aa5-33, AP) - LS-C240196 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3H Antibody (aa5-33, Biotin) - LS-C240198 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3H Antibody (aa5-33, APC) - LS-C240197 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3H Antibody (aa5-33, FITC) - LS-C240200 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3H Antibody (aa5-33, PE) - LS-C240201 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3H Antibody (aa5-33, Azide-free, HRP) - LS-C248040 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3H Antibody (aa10-40) - LS-C324773 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3H Antibody (C-Terminus) - LS-C111181 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
POLR3H antibody LS-C111181 Western blot of Fetal Muscle lysate.

Anti-POLR3H Antibody (aa151-200) - LS-C119921 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from K562 cells, using RPC8 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-POLR3H Antibody (aa5-33) - LS-C162690 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of RPC8 Antibody in mouse testis tissue lysates (35 ug/lane). RPC8 (arrow) was detected using the purified antibody.

POLR3H Antibody - NBP2-13787 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: POLR3H Antibody [NBP2-13787] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & centrosome.

POLR3H Antibody - NBP1-53025 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: POLR3H Antibody [NBP1-53025] - Human Muscle lysate, concentration 0.2-1 ug/ml.

Anti-POLR3H antibody produced in rabbit - SAB2101844 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-POLR3H: <B>Cat. No.SAB2101844</B>: POLR3H in Fetal Muscle tissue lysate with POLR3H antibody at 1.0 μg/mL.

Anti-POLR3H (11-25) antibody produced in rabbit - SAB1103658 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human POLR3H was separated on SDS-PAGE, blotted with Anti-POLR3H (11-25) (<B>Cat. No. SAB1103658</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + POLR3H immunizing peptide (human, 11-25)

Anti-POLR3H (131-145) antibody produced in rabbit - SAB1103659 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human POLR3H was separated on SDS-PAGE, blotted with Anti-POLR3H (131-145) (<B>Cat. No. SAB1103659</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500 <BR/>2. Antibody dilution 1:500 + POLR3H immunizing peptide (human, 131-145)

Anti-POLR3H antibody produced in rabbit - HPA046787 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-POLR3H:<B>Cat. No. HPA046787</B>: Immunohistochemical staining of human stomach, lower shows moderate nuclear positivity in glandular cells.

Anti-RPC8, C-Terminal antibody produced in rabbit - SAB4500652 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RPC8, C-Terminal: <B>Cat. No. SAB4500652</B>: Immunoblotting analysis of extracts from K562 cells, using Anti-RPC8, C-Terminal antibody. The lane on the left was treated with the Anti-RPC8, C-Terminal antibody. The lane on the right (negative control) was treated with both Anti-RPC8, C-Terminal antibody and the synthesized immunogen peptide.

ANTI-RPC8(N-TERMINAL) antibody produced in rabbit - SAB1305362 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RPC8 (N-term): <B>Cat. No. SAB1305362</B>: Western blot analysis of RPC8 Antibody (N-term) in Mouse testis tissue lysates (35 μg/lane).

POLR3H antibody - middle region (ARP48519_P050) - ARP48519_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

POLR3H Antibody - N-terminal region (OAAB02351) - OAAB02351 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

RPC8-Antibody-N-term - AP4936a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of RPC8 Antibody (N-term) (Cat. #AP4936a) in mouse testis tissue lysates (35ug/lane). RPC8 (arrow) was detected using the purified Pab.
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