POLR3H
| Gene Symbol | POLR3H |
|---|---|
| Entrez Gene | 171568 |
| Alt Symbol | RPC22.9, RPC8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) |
| Other Description | DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide|DNA-directed RNA polymerase III subunit H|DNA-directed RNA polymerase III subunit RPC8|RNA nucleotidyltransferase (DNA-directed)|RNA polymerase III subunit C8 |
| Swissprots | Q96AE3 Q9Y535 Q9BY95 Q5M7Y8 B0QYH9 |
| Accessions | EAW60437 EAW60438 EAW60439 EAW60440 EAW60441 Q9Y535 AB051452 BAB33335 AK000365 AK026524 AK129663 BAC85211 AY092087 AAM18217 BC017248 AAH17248 BC088367 AAH88367 BI754673 BM681267 BM701572 BU173504 BU584298 BU928882 BX331353 BX367405 CB126821 CR456459 CAG30345 CU013009 CAK54440 CU013297 CAK54739 DA238361 DA449644 DA504810 GQ129271 ACT64405 GQ129272 ACT64406 XM_011529993 XP_011528295 XR_244356 NM_001018051 NM_001018050 NP_001018060 NM_001018052 NP_001018062 NM_001282884 NP_001269813 NM_001282885 NP_001269814 NM_138338 NP_612211 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. |
| Top Pathways | Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |
POLR3H CRISPR/Cas9 KO Plasmid (h) - sc-410648 from Santa Cruz Biotechnology
|
||||||||
POLR3H HDR Plasmid (h) - sc-410648-HDR from Santa Cruz Biotechnology
|
||||||||
POLR3H Double Nickase Plasmid (h) - sc-410648-NIC from Santa Cruz Biotechnology
|
||||||||
POLR3H Double Nickase Plasmid (h2) - sc-410648-NIC-2 from Santa Cruz Biotechnology
|
||||||||
POLR3H CRISPR Activation Plasmid (h) - sc-410648-ACT from Santa Cruz Biotechnology
|
||||||||
POLR3H CRISPR Activation Plasmid (h2) - sc-410648-ACT-2 from Santa Cruz Biotechnology
|
||||||||
POLR3H Lentiviral Activation Particles (h) - sc-410648-LAC from Santa Cruz Biotechnology
|
||||||||
POLR3H Lentiviral Activation Particles (h2) - sc-410648-LAC-2 from Santa Cruz Biotechnology
|
||||||||
POLR3H siRNA (h) - sc-76194 from Santa Cruz Biotechnology
|
||||||||
POLR3H shRNA Plasmid (h) - sc-76194-SH from Santa Cruz Biotechnology
|
||||||||
POLR3H shRNA (h) Lentiviral Particles - sc-76194-V from Santa Cruz Biotechnology
|
||||||||
POLR3H RNAi - H00171568-R04 from Novus Biologicals
|
||||||||
POLR3H RNAi - H00171568-R01 from Novus Biologicals
|
||||||||
POLR3H RNAi - H00171568-R03 from Novus Biologicals
|
||||||||
POLR3H RNAi - H00171568-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU062981 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17134 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17134 from Sigma-Aldrich
|
||||||||
POLR3H siRNA (Human) - CRJ6149 from Cohesion Biosciences
|
||||||||
shRNA set against Human POLR3H (NM_138338.3) - SHH379624 from Creative biogene
|
||||||||
Human POLR3H siRNA - orb276650 from Biorbyt
|
||||||||
POLR3H shRNA Plasmid (Human) - CHJ6149 from Cohesion Biosciences
|