| Gene Symbol |
Tpx2
|
| Entrez Gene |
72119
|
| Alt Symbol |
2610005B21Rik, DIL2, REPP86, p100
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
TPX2, microtubule-associated protein homolog (Xenopus laevis)
|
| Other Description |
targeting protein for Xklp2
|
| Swissprots |
Q6P9S6 Q3U500 A2APB8
|
| Accessions |
A2APB8 EDL05994 EDL05995 EDL05996 EDL05997 AK011311 BAB27537 AK090101 BAC41092 AK153957 BAE32280 AK167030 AK190284 BC060619 AAH60619 BU148033 BU612544 CA327246 CA558942 CJ163921 CO434548 CV555694 XM_006500213 XP_006500276 XM_006500214 XP_006500277 XM_006500215 XP_006500278 NM_001141975 NP_001135447 NM_001141976 NP_001135448 NM_001141977 NP_001135449 NM_001141978 NP_001135450 NM_028109 NP_082385
|
| Function |
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18663142}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18663142}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules (By similarity). {ECO:0000250}.
|