Gene Symbol | Tpx2 |
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Entrez Gene | 72119 |
Alt Symbol | 2610005B21Rik, DIL2, REPP86, p100 |
Species | Mouse |
Gene Type | protein-coding |
Description | TPX2, microtubule-associated protein homolog (Xenopus laevis) |
Other Description | targeting protein for Xklp2 |
Swissprots | Q6P9S6 Q3U500 A2APB8 |
Accessions | A2APB8 EDL05994 EDL05995 EDL05996 EDL05997 AK011311 BAB27537 AK090101 BAC41092 AK153957 BAE32280 AK167030 AK190284 BC060619 AAH60619 BU148033 BU612544 CA327246 CA558942 CJ163921 CO434548 CV555694 XM_006500213 XP_006500276 XM_006500214 XP_006500277 XM_006500215 XP_006500278 NM_001141975 NP_001135447 NM_001141976 NP_001135448 NM_001141977 NP_001135449 NM_001141978 NP_001135450 NM_028109 NP_082385 |
Function | Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18663142}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18663142}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules (By similarity). {ECO:0000250}. |
TPX2 CRISPR/Cas9 KO Plasmid (m) - sc-428241 from Santa Cruz Biotechnology
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TPX2 HDR Plasmid (m) - sc-428241-HDR from Santa Cruz Biotechnology
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TPX2 Double Nickase Plasmid (m) - sc-428241-NIC from Santa Cruz Biotechnology
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TPX2 Double Nickase Plasmid (m2) - sc-428241-NIC-2 from Santa Cruz Biotechnology
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TPX2 CRISPR Activation Plasmid (m) - sc-428241-ACT from Santa Cruz Biotechnology
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TPX2 CRISPR Activation Plasmid (m2) - sc-428241-ACT-2 from Santa Cruz Biotechnology
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TPX2 Lentiviral Activation Particles (m) - sc-428241-LAC from Santa Cruz Biotechnology
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TPX2 Lentiviral Activation Particles (m2) - sc-428241-LAC-2 from Santa Cruz Biotechnology
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TPX2 siRNA (m) - sc-37654 from Santa Cruz Biotechnology
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TPX2 shRNA Plasmid (m) - sc-37654-SH from Santa Cruz Biotechnology
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TPX2 shRNA (m) Lentiviral Particles - sc-37654-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU068571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN43362 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43362 from Sigma-Aldrich
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TPX2 siRNA (Mouse) - CRM8704 from Cohesion Biosciences
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TPX2 - MBS8226798 from MyBioSource
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shRNA set against Mouse TPX2 (NM_028109.4) - SHH433624 from Creative biogene
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Mouse TPX2 siRNA - orb288180 from Biorbyt
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TPX2 shRNA Plasmid (Mouse) - CHM8704 from Cohesion Biosciences
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