| Gene Symbol | Tpx2 |
|---|---|
| Entrez Gene | 72119 |
| Alt Symbol | 2610005B21Rik, DIL2, REPP86, p100 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | TPX2, microtubule-associated protein homolog (Xenopus laevis) |
| Other Description | targeting protein for Xklp2 |
| Swissprots | Q6P9S6 Q3U500 A2APB8 |
| Accessions | A2APB8 EDL05994 EDL05995 EDL05996 EDL05997 AK011311 BAB27537 AK090101 BAC41092 AK153957 BAE32280 AK167030 AK190284 BC060619 AAH60619 BU148033 BU612544 CA327246 CA558942 CJ163921 CO434548 CV555694 XM_006500213 XP_006500276 XM_006500214 XP_006500277 XM_006500215 XP_006500278 NM_001141975 NP_001135447 NM_001141976 NP_001135448 NM_001141977 NP_001135449 NM_001141978 NP_001135450 NM_028109 NP_082385 |
| Function | Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18663142}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18663142}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules (By similarity). {ECO:0000250}. |
Mouse Tpx2 ORF clone - CDCH094452 from Creative Biomart
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Mouse Tpx2 ORF clone - CDCH094453 from Creative Biomart
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Mouse TPX2 ORF clone(NM_028109.4) - CDCG003661 from Creative Biomart
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Mouse TPX2 ORF clone(NM_001141975.1) - CDCG003662 from Creative Biomart
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Mouse TPX2 ORF clone(NM_001141976.1) - CDCG003664 from Creative Biomart
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Mouse TPX2 ORF clone(NM_001141977.1) - CDCG003666 from Creative Biomart
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Mouse TPX2 ORF clone(NM_001141978.1) - CDCG003668 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_001141975.1) - CDCR237842 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_001141975.1) - CDCR237843 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_001141976.1) - CDCR237844 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_001141976.1) - CDCR237845 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_001141977.1) - CDCR237846 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_001141977.1) - CDCR237847 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_001141978.1) - CDCR237848 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_028109.4) - CDCR261066 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_028109.4) - CDCR261067 from Creative Biomart
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Mouse Tpx2 ORF Clone(NM_001141976.1) - CDCR237844 from Creative biogene
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Mouse Tpx2 ORF Clone(NM_001141977.1) - CDCR237846 from Creative biogene
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Mouse Tpx2 ORF Clone(NM_001141978.1) - CDCR237848 from Creative biogene
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Mouse Tpx2 ORF Clone(NM_028109.4) - CDCR261066 from Creative biogene
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Mouse Tpx2 ORF clone (NM_001141975.1) - CDCH094452 from Creative biogene
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