ARF6

Gene Symbol ARF6
Entrez Gene 382
Alt Symbol -
Species Human
Gene Type protein-coding
Description ADP-ribosylation factor 6
Other Description -
Swissprots P62330 Q6FGZ2
Accessions AAP50257 EAW65740 P62330 AF047432 AAC39877 AF493885 AAM12599 AK313790 BAG36527 AL117621 AL121163 BC002952 BC008918 AAH08918 BC030291 BM838197 BT019868 AAV38671 CR541939 CAG46737 CR541964 CAG46762 DA217686 M57763 AAA90928 NM_001663 NP_001654
Function GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000269|PubMed:11266366, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:18400762, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:7589240}.
Subcellular Location Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell projection, filopodium membrane; Lipid-anchor. Midbody {ECO:0000250}. Cytoplasm {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. {ECO:0000250}.
Tissue Specificity Ubiquitous, with higher levels in heart, substantia nigra, and kidney. {ECO:0000269|PubMed:14659046}.
Top Pathways Fc gamma R-mediated phagocytosis, Endocytosis

ARF6-Over-expression-Lysate - LY11637a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag ARF6 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ARF6 gene

ARF6 overexpression lysate - LY400629 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

ARF6 293 Cell Lysate - 400619 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

ARF6 Overexpression Lysate (Native) - NBL1-07654 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: ARF6 Overexpression Lysate (Adult Normal) [NBL1-07654] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ARF6.

ARF6 Over-expression Lysate Product - GWB-C4E632 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human ARF6 Knockdown Stable Cell Line - CSC-DC000833 from Creative biogene

Category Cell Line
Species Human
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