| Gene Symbol | ARF6 |
|---|---|
| Entrez Gene | 382 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADP-ribosylation factor 6 |
| Other Description | - |
| Swissprots | P62330 Q6FGZ2 |
| Accessions | AAP50257 EAW65740 P62330 AF047432 AAC39877 AF493885 AAM12599 AK313790 BAG36527 AL117621 AL121163 BC002952 BC008918 AAH08918 BC030291 BM838197 BT019868 AAV38671 CR541939 CAG46737 CR541964 CAG46762 DA217686 M57763 AAA90928 NM_001663 NP_001654 |
| Function | GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000269|PubMed:11266366, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:18400762, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:7589240}. |
| Subcellular Location | Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell projection, filopodium membrane; Lipid-anchor. Midbody {ECO:0000250}. Cytoplasm {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. {ECO:0000250}. |
| Tissue Specificity | Ubiquitous, with higher levels in heart, substantia nigra, and kidney. {ECO:0000269|PubMed:14659046}. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Endocytosis |