ARF6

Gene Symbol ARF6
Entrez Gene 382
Alt Symbol -
Species Human
Gene Type protein-coding
Description ADP-ribosylation factor 6
Other Description -
Swissprots P62330 Q6FGZ2
Accessions AAP50257 EAW65740 P62330 AF047432 AAC39877 AF493885 AAM12599 AK313790 BAG36527 AL117621 AL121163 BC002952 BC008918 AAH08918 BC030291 BM838197 BT019868 AAV38671 CR541939 CAG46737 CR541964 CAG46762 DA217686 M57763 AAA90928 NM_001663 NP_001654
Function GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000269|PubMed:11266366, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:18400762, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:7589240}.
Subcellular Location Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell projection, filopodium membrane; Lipid-anchor. Midbody {ECO:0000250}. Cytoplasm {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. {ECO:0000250}.
Tissue Specificity Ubiquitous, with higher levels in heart, substantia nigra, and kidney. {ECO:0000269|PubMed:14659046}.
Top Pathways Fc gamma R-mediated phagocytosis, Endocytosis

Arf6 Antibody - 3546 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Arf6 Antibody.

Arf6 (D12G6) Rabbit mAb - 5740 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D12G6
Western blot analysis of extracts from various cell lines, using Arf6 (D12G6) Rabbit mAb.

ARF6 (3A-1) - sc-7971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARF6 (3A-1): sc-7971. Western blot analysis of ARF6 expression in KNRK whole cell lysate.

Anti-ARF6 antibody - ab155929 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ARF6 antibody (ab155929) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLane 3 : 293T whole cell lysateLane 4 : A431 whole cell lysateLane 5 : Jurkat whole cell lysateLane 6 : MCF7 whole cell lysateLane 7 : U2OS whole cell lysateLane 8 : K562 whole cell lysateLane 9 : COS7 whole cell lysateLane 10 : MEF whole cell lysateLane 11 : 3T3L1 whole cell lysateLysates/proteins at 50 µg per lane.SecondaryGoat anti-rabbit HRP conjugated antibody at 1/10000 dilutiondeveloped using the ECL technique

Anti-ARF6 antibody - ab199618 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ARF6 antibody (ab199618) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : 293T cell lysateLysates/proteins at 35 µg per lane.Secondarygoat anti-rabbit IgG H&L(HRP) at 1/5000 dilutiondeveloped using the ECL technique

Anti-ARF6 antibody - ab54832 from Abcam

Host Mouse
Clonality Monoclonal
Anti-ARF6 antibody (ab54832) at 1/500 dilution + Recombinant human ARF6 at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

Anti-ARF6 antibody [6ARF01] - ab76553 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6ARF01

Anti-ARF6 antibody [EPR8357] - ab131261 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8357
All lanes : Anti-ARF6 antibody [EPR8357] (ab131261) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : 293T cell lysateLane 3 : A431 cell lysateLysates/proteins at 10 µg per lane.

Anti-ARF6 antibody [SPM371] - ab19871 from Abcam

Host Mouse
Clonality Monoclonal
Clone SPM371

Anti-Arf6 antibody - C-terminal - ab181000 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Arf6 antibody - C-terminal (ab181000) at 1 µg + rat liver tissue lysate at 15 µg

Anti-ARF6 Antibody - LS-C3569 from LifeSpan Bioscience

Prices $455.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-ARF6 Antibody (clone 6ARF01) - LS-C87645 from LifeSpan Bioscience

Prices $265.00, $555.00, $925.00
Sizes 100 µl, 500 µl, 1 ml
Host Mouse
Clonality Monoclonal
Clone 6ARF01

Anti-ARF6 Antibody (clone 6ARF01, Azide-free) - LS-C87646 from LifeSpan Bioscience

Prices $610.00, $995.00
Sizes 100 µl, 200 µl
Host Mouse
Clonality Monoclonal
Clone 6ARF01

Anti-ARF6 Antibody - LS-C126630 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ARF6 Antibody (aa114-159) - LS-C313671 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARF6 Antibody (C-Terminus) - LS-C201193 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of ARF6 in rat liver tissue lysate with ARF6 antibody at 1 ug/ml.

Anti-ARF6 Antibody (Internal, clone EPR8357) - LS-C154559 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8357
Immunofluorescent staining of HeLa cells using anti-ARF6 antibody.

Anti-ARF6 Antibody (clone 2A4) - LS-C196686 from LifeSpan Bioscience

Prices $355.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2A4
Western Blot analysis of ARF6 expression in transfected 293T cell line by ARF6 monoclonal antibody (M01A), clone 2A4.Lane 1: ARF6 transfected lysate (Predicted MW: 20.1 KDa).Lane 2: Non-transfected lysate.

Anti-ARF6 Antibody - LS-C192313 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ARF6 pAb in extracts from A431 and 293T cells.

Anti-ARF6 Antibody - LS-C331185 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of A431 cell and 293T cell lysate using ARF6 antibody.

Anti-ARF6 Antibody (aa125-174) - LS-C206110 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ARF6 antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.

Anti-ARF6 Antibody - LS-C332390 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human breast cancer tissue using ARF6 antibody.

Anti-ARF6 Antibody (aa126-155) - LS-C156452 from LifeSpan Bioscience

Prices $250.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with ARF6 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Anti-ARF6 Antibody (aa84-113) IHC-plus™ - LS-B11684 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-ARF6 Antibody (C-Terminus) IHC-plus™ - LS-B5846 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ARF6 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5846 concentration 5 ug/ml.
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