| Gene Symbol | PPIP5K2 |
|---|---|
| Entrez Gene | 23262 |
| Alt Symbol | HISPPD1, IP7K2, VIP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | diphosphoinositol pentakisphosphate kinase 2 |
| Other Description | VIP1 homolog 2|histidine acid phosphatase domain-containing protein 1|inositol heptaphosphate kinase 2|inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2|insP6 and PP-IP5 kinase 2 |
| Swissprots | A6NGS8 Q8TB50 O43314 A1NI53 |
| Accessions | EAW49076 EAW49077 EAW49078 EAW49079 O43314 AB007893 BAA24863 AK025159 AK027116 AK294787 BAG57912 BC024591 AAH24591 DB298507 DC404725 XM_005271935 XP_005271992 XM_005271936 XP_005271993 XM_005271938 XP_005271995 XM_005277534 XP_005277591 XM_005277535 XP_005277592 XM_005277536 XP_005277593 XM_005277538 XP_005277595 XM_005277539 XP_005277596 XM_005277541 XP_005277598 XM_006714576 XP_006714639 XM_006714577 XP_006714640 XM_011543290 XP_011541592 NR_074081 NM_001276277 NP_001263206 NM_001281471 NP_001268400 NM_015216 NP_056031 |
| Function | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:17690096}. |
HISPPD1 (h): 293T Lysate - sc-113677 from Santa Cruz Biotechnology
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Panoply™ Human PPIP5K2 Knockdown Stable Cell Line - CSC-DC012210 from Creative biogene
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