| Gene Symbol |
DCLK2
|
| Entrez Gene |
166614
|
| Alt Symbol |
CL2, CLICK-II, CLICK2, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
doublecortin-like kinase 2
|
| Other Description |
CaMK-like CREB regulatory kinase 2|doublecortin and CaM kinase-like 2|doublecortin domain-containing protein 3B|doublecortin-like and CAM kinase-like 2|serine/threonine-protein kinase DCLK2
|
| Swissprots |
Q8N568 Q8N399 C9J5Q9 Q59GC8
|
| Accessions |
AAY40983 EAX05001 EAX05002 EAX05003 Q8N568 AB209181 BAD92418 AI419589 AL834498 CAD39156 BC019831 BC032726 BC172430 AAI72430 DA122884 DA201927 DQ890892 ABM81818 DQ893344 ABM84270 DQ896665 ABM87664 XM_005262785 XP_005262842 XM_005262786 XP_005262843 XR_244621 NM_001040260 NP_001035350 NM_001040261 NP_001035351 NR_036614 NM_152619
|
| Function |
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the brain, heart and eyes. {ECO:0000269|PubMed:18075264}.
|