Gene Symbol | DCLK2 |
---|---|
Entrez Gene | 166614 |
Alt Symbol | CL2, CLICK-II, CLICK2, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2 |
Species | Human |
Gene Type | protein-coding |
Description | doublecortin-like kinase 2 |
Other Description | CaMK-like CREB regulatory kinase 2|doublecortin and CaM kinase-like 2|doublecortin domain-containing protein 3B|doublecortin-like and CAM kinase-like 2|serine/threonine-protein kinase DCLK2 |
Swissprots | Q8N568 Q8N399 C9J5Q9 Q59GC8 |
Accessions | AAY40983 EAX05001 EAX05002 EAX05003 Q8N568 AB209181 BAD92418 AI419589 AL834498 CAD39156 BC019831 BC032726 BC172430 AAI72430 DA122884 DA201927 DQ890892 ABM81818 DQ893344 ABM84270 DQ896665 ABM87664 XM_005262785 XP_005262842 XM_005262786 XP_005262843 XR_244621 NM_001040260 NP_001035350 NM_001040261 NP_001035351 NR_036614 NM_152619 |
Function | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}. |
Tissue Specificity | Expressed in the brain, heart and eyes. {ECO:0000269|PubMed:18075264}. |
DCAMKL2 CRISPR/Cas9 KO Plasmid (h) - sc-414892 from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 HDR Plasmid (h) - sc-414892-HDR from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 Double Nickase Plasmid (h) - sc-414892-NIC from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 Double Nickase Plasmid (h2) - sc-414892-NIC-2 from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 CRISPR Activation Plasmid (h) - sc-414892-ACT from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 CRISPR Activation Plasmid (h2) - sc-414892-ACT-2 from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 Lentiviral Activation Particles (h) - sc-414892-LAC from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 Lentiviral Activation Particles (h2) - sc-414892-LAC-2 from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 siRNA (h) - sc-105272 from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 shRNA Plasmid (h) - sc-105272-SH from Santa Cruz Biotechnology
|
||||||||
DCAMKL2 shRNA (h) Lentiviral Particles - sc-105272-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU089701 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0554 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0555 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0553 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN6989 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6989 from Sigma-Aldrich
|
||||||||
DCLK2 siRNA (Human) - CRJ6042 from Cohesion Biosciences
|
||||||||
DCAMKL2 RNAi - H00166614-R02 from Novus Biologicals
|
||||||||
DCLK2 - MBS8239233 from MyBioSource
|
||||||||
shRNA set against Human DCLK2 (NM_001040260.3) - SHH275181 from Creative biogene
|
||||||||
DCLK2 shRNA Plasmid (Human) - CHJ6042 from Cohesion Biosciences
|
||||||||
DCLK2 miRNA 3'UTR clone - MiUTR3H-12763 from Creative biogene
|
||||||||
DCLK2 miRNA 3'UTR clone - MiUTR3H-12764 from Creative biogene
|