Gene Symbol | RBM17 |
---|---|
Entrez Gene | 84991 |
Alt Symbol | SPF45 |
Species | Human |
Gene Type | protein-coding |
Description | RNA binding motif protein 17 |
Other Description | 45 kDa-splicing factor|RNA-binding motif protein 17|splicing factor 45|splicing factor 45kDa |
Swissprots | Q96I25 Q96GY6 |
Accessions | CCQ43786 EAW86405 EAW86406 EAW86407 EAW86408 EAW86409 EAW86410 EAW86411 Q96I25 AA905075 AF542550 AAQ09533 AK021863 AK314952 BAG37457 BC007871 AAH07871 BC009064 AAH09064 BC039322 AAH39322 BX648288 CN291330 CV570433 HQ448221 ADQ32701 NM_001145547 NP_001139019 NM_032905 NP_116294 |
Function | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9731529}. |
Top Pathways | Spliceosome |
RBM17 CRISPR/Cas9 KO Plasmid (h) - sc-405390 from Santa Cruz Biotechnology
|
||||||||
RBM17 HDR Plasmid (h) - sc-405390-HDR from Santa Cruz Biotechnology
|
||||||||
RBM17 Double Nickase Plasmid (h) - sc-405390-NIC from Santa Cruz Biotechnology
|
||||||||
RBM17 Double Nickase Plasmid (h2) - sc-405390-NIC-2 from Santa Cruz Biotechnology
|
||||||||
RBM17 CRISPR Activation Plasmid (h) - sc-405390-ACT from Santa Cruz Biotechnology
|
||||||||
RBM17 CRISPR Activation Plasmid (h2) - sc-405390-ACT-2 from Santa Cruz Biotechnology
|
||||||||
RBM17 Lentiviral Activation Particles (h) - sc-405390-LAC from Santa Cruz Biotechnology
|
||||||||
RBM17 Lentiviral Activation Particles (h2) - sc-405390-LAC-2 from Santa Cruz Biotechnology
|
||||||||
RBM17 siRNA (h) - sc-90676 from Santa Cruz Biotechnology
|
||||||||
RBM17 shRNA Plasmid (h) - sc-90676-SH from Santa Cruz Biotechnology
|
||||||||
RBM17 shRNA (h) Lentiviral Particles - sc-90676-V from Santa Cruz Biotechnology
|
||||||||
RBM17 RNAi - H00084991-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU014451 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN18029 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18029 from Sigma-Aldrich
|
||||||||
RBM17 siRNA (Human) - CRJ3747 from Cohesion Biosciences
|
||||||||
RBM17 - MBS8235398 from MyBioSource
|
||||||||
shRNA set against Human RBM17 (NM_032905.4) - SHH390576 from Creative biogene
|
||||||||
Human RBM17 siRNA - orb274248 from Biorbyt
|
||||||||
RBM17 shRNA Plasmid (Human) - CHJ3747 from Cohesion Biosciences
|
||||||||
RBM17 miRNA 3'UTR clone - MiUTR3H-08837 from Creative biogene
|
||||||||
RBM17 miRNA 3'UTR clone - MiUTR3H-08838 from Creative biogene
|