| Gene Symbol | KIF2C |
|---|---|
| Entrez Gene | 11004 |
| Alt Symbol | CT139, KNSL6, MCAK |
| Species | Human |
| Gene Type | protein-coding |
| Description | kinesin family member 2C |
| Other Description | kinesin-like protein 6|kinesin-like protein KIF2C|mitotic centromere-associated kinesin |
| Swissprots | Q5JR88 B3ITR9 Q96HB8 Q6ICU1 Q99661 Q9BWV8 Q96C18 |
| Accessions | EAX07025 Q99661 AB264115 BAG50306 AK290688 BAF83377 AK300756 BAH13342 AK302267 BAH13662 AK312606 AL046197 AU130795 AY026505 AAK20168 BC008764 AAH08764 BC014924 AAH14924 BC032038 AAH32038 BT006759 AAP35405 BU615368 CR450302 CAG29298 DB045012 DC399082 DC404550 DQ893800 ABM84726 EU176178 ABW03629 U63743 AAC27660 XM_011540540 XP_011538842 XM_011540541 XP_011538843 NM_001297655 NP_001284584 NM_001297656 NP_001284585 NM_001297657 NP_001284586 NM_006845 NP_006836 |
| Function | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}. |
| Tissue Specificity | Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. {ECO:0000269|PubMed:12383881, ECO:0000269|PubMed:9434124}. |