KIF2C

Gene Symbol	KIF2C
Entrez Gene	11004
Alt Symbol	CT139, KNSL6, MCAK
Species	Human
Gene Type	protein-coding
Description	kinesin family member 2C
Other Description	kinesin-like protein 6|kinesin-like protein KIF2C|mitotic centromere-associated kinesin
Swissprots	Q5JR88 B3ITR9 Q96HB8 Q6ICU1 Q99661 Q9BWV8 Q96C18
Accessions	EAX07025 Q99661 AB264115 BAG50306 AK290688 BAF83377 AK300756 BAH13342 AK302267 BAH13662 AK312606 AL046197 AU130795 AY026505 AAK20168 BC008764 AAH08764 BC014924 AAH14924 BC032038 AAH32038 BT006759 AAP35405 BU615368 CR450302 CAG29298 DB045012 DC399082 DC404550 DQ893800 ABM84726 EU176178 ABW03629 U63743 AAC27660 XM_011540540 XP_011538842 XM_011540541 XP_011538843 NM_001297655 NP_001284584 NM_001297656 NP_001284585 NM_001297657 NP_001284586 NM_006845 NP_006836
Function	In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}.
Tissue Specificity	Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. {ECO:0000269|PubMed:12383881, ECO:0000269|PubMed:9434124}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MCAK full length protein - ab132006 from Abcam Category Protein Source Wheat germ Species Human

Human MCAK peptide - ab42675 from Abcam Category Peptide

Human MCAK peptide - ab23137 from Abcam Category Peptide Species Human

Human MCAK protein fragment - ab153148 from Abcam Category Protein Source Wheat germ Species Human

KIF2C / MCAK Antibody Blocking Peptide - LS-E2918 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KIF2C / MCAK Antibody Blocking Peptide - LS-E12000 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KIF2C Protein - H00011004-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human KIF2C Protein - H00011004-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KIF2C-Antibody-N-term-Blocking-peptide - BP14043a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KIF2C Blocking Peptide - 33R-5021 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KIF2C - H00011004-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KIF2C - H00011004-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KIF2C - H00011004-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KIF2C - H00011004-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KIF2C fusion protein - Ag2786 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human KIF2C, GST-tagged - KIF2C-372H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Kinesin-like protein KIF2C(KIF2C) - CSB-YP860347HU CSB-EP860347HU CSB-BP860347HU CSB-MP860347HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KIF2C - TP300254 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

KIF2C Protein - NBP1-82870PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

KIF2C (pS95) Blocking Peptide - abx161917 from Abbexa Category Peptide Species Human, Monkey

KIF2C Peptide, Human - M34GP08197H from Creative Peptides Category Peptide Source Synthetic. Species Human

KIF2C (pS95) Blocking Peptide - CBP4706 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Monkey

Kinesin-like protein KIF2C (KIF2C), Recombinant Protein - MBS1432231 from MyBioSource Category Protein Prices $1,535.00, $1,535.00, $1,760.00, $1,760.00, $2,630.00, $2,630.00, $3,075.00, $3,075.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

KIF2C (Phospho-S95) peptide - orb315850 from Biorbyt Category Peptide

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