KIF2C

Gene Symbol KIF2C
Entrez Gene 11004
Alt Symbol CT139, KNSL6, MCAK
Species Human
Gene Type protein-coding
Description kinesin family member 2C
Other Description kinesin-like protein 6|kinesin-like protein KIF2C|mitotic centromere-associated kinesin
Swissprots Q5JR88 B3ITR9 Q96HB8 Q6ICU1 Q99661 Q9BWV8 Q96C18
Accessions EAX07025 Q99661 AB264115 BAG50306 AK290688 BAF83377 AK300756 BAH13342 AK302267 BAH13662 AK312606 AL046197 AU130795 AY026505 AAK20168 BC008764 AAH08764 BC014924 AAH14924 BC032038 AAH32038 BT006759 AAP35405 BU615368 CR450302 CAG29298 DB045012 DC399082 DC404550 DQ893800 ABM84726 EU176178 ABW03629 U63743 AAC27660 XM_011540540 XP_011538842 XM_011540541 XP_011538843 NM_001297655 NP_001284584 NM_001297656 NP_001284585 NM_001297657 NP_001284586 NM_006845 NP_006836
Function In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}.
Tissue Specificity Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. {ECO:0000269|PubMed:12383881, ECO:0000269|PubMed:9434124}.

KIF2C (D-15) - sc-30277 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KIF2C (D-15): sc-30277. Western blot analysis of KIF2C expression in HeLa whole cell lysate.

KIF2C (N-14) - sc-30276 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KIF2C (2488C3a) - sc-81305 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
KIF2C (2488C3a): sc-81305 Western Blot analysis of human recombinant KIF2C fusion protein.

Anti-MCAK (phospho S95) antibody - ab74146 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab74146, at 1/500 dilution, staining A549 cells using immunofluorescence analysis, in the absence and presence of the immunising phosphopeptide.

Anti-MCAK antibody - ab42676 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MCAK antibody (ab42676) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 4 : HEK293 Human embryonic kidney cell line Whole Cell Lysate Lane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-MCAK antibody - ab70536 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin carcinoma (left) and breast carcinoma (right) tissues labelling MCAK with ab70536 at 1/1000 (1µg/ml). Detection: DAB.

Anti-MCAK antibody - ab95126 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab95126, at 1/250 dilution, staining MCAK in formalin-fixed, paraffin-embedded Human colon carcinoma by Immunohistochemistry, using DAB staining.

Anti-MCAK antibody - ab116522 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MCAK antibody (ab116522) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

Anti-MCAK antibody [2488C3a] - ab50778 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2488C3a
Anti-MCAK antibody [2488C3a] (ab50778) + immunizing peptide

Anti-MCAK antibody [EPR14838] - ab187652 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14838
Flow cytometric analysis of HeLa cells labeling MCAK with ab187652 at 1/260 dilution compared to negative control cells. Secondary antibody FITC-conjugated goat-anti-rabbit IgG used at 1/150 diution.

Anti-KIF2C / MCAK Antibody (clone 1C5) - LS-C337448 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C5
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-KIF2C mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-KIF2C / MCAK Antibody (aa531-725) - LS-C344083 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MCAK antibody IHC-paraffin: Rat Thymus Tissue.

Anti-KIF2C / MCAK Antibody (aa50-100) - LS-C286203 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse MCAK by Immunohistochemistry. Sample: FFPE section of mouse hybridoma tumor. Antibody: Affinity purified rabbit anti-MCAK used at a dilution of 1:250. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.

Anti-KIF2C / MCAK Antibody (clone 2488C3a) - LS-C342484 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2488C3a
Western blot analysis of immunized recombinant protein, using anti-KIF2C monoclonal antibody.

Anti-KIF2C / MCAK Antibody (aa50-100) IHC-plus™ - LS-B11306 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-KIF2C / MCAK antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11306 concentration 5 ug/ml.

Anti-KIF2C / MCAK Antibody (clone 1G2) - LS-C133671 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G2
Immunoperoxidase of monoclonal antibody to KIF2C on formalin-fixed paraffin-embedded human malignant lymphoma, diffuse large B. [antibody concentration 3 ug/ml].

Anti-KIF2C / MCAK Antibody - LS-C334067 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human stomach using KIF2C antibody at dilution of 1:200 (200x lens).

Anti-KIF2C / MCAK Antibody - LS-C48683 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KIF2C / MCAK Antibody - LS-C71371 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-KIF2C / MCAK Antibody (aa550-600) - LS-C71376 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KIF2C / MCAK Antibody (aa50-100) - LS-C71373 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KIF2C / MCAK Antibody (aa550-600) - LS-C71374 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KIF2C / MCAK Antibody (aa179-208, AP) - LS-C261143 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIF2C / MCAK Antibody (aa179-208, Biotin) - LS-C261144 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIF2C / MCAK Antibody (aa179-208, APC) - LS-C261145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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