KIF2C

Gene Symbol	KIF2C
Entrez Gene	11004
Alt Symbol	CT139, KNSL6, MCAK
Species	Human
Gene Type	protein-coding
Description	kinesin family member 2C
Other Description	kinesin-like protein 6|kinesin-like protein KIF2C|mitotic centromere-associated kinesin
Swissprots	Q5JR88 B3ITR9 Q96HB8 Q6ICU1 Q99661 Q9BWV8 Q96C18
Accessions	EAX07025 Q99661 AB264115 BAG50306 AK290688 BAF83377 AK300756 BAH13342 AK302267 BAH13662 AK312606 AL046197 AU130795 AY026505 AAK20168 BC008764 AAH08764 BC014924 AAH14924 BC032038 AAH32038 BT006759 AAP35405 BU615368 CR450302 CAG29298 DB045012 DC399082 DC404550 DQ893800 ABM84726 EU176178 ABW03629 U63743 AAC27660 XM_011540540 XP_011538842 XM_011540541 XP_011538843 NM_001297655 NP_001284584 NM_001297656 NP_001284585 NM_001297657 NP_001284586 NM_006845 NP_006836
Function	In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}.
Tissue Specificity	Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. {ECO:0000269|PubMed:12383881, ECO:0000269|PubMed:9434124}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KIF2C CRISPR/Cas9 KO Plasmid (h) - sc-404645 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

KIF2C HDR Plasmid (h) - sc-404645-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KIF2C Double Nickase Plasmid (h) - sc-404645-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KIF2C Double Nickase Plasmid (h2) - sc-404645-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KIF2C CRISPR Activation Plasmid (h) - sc-404645-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

KIF2C CRISPR Activation Plasmid (h2) - sc-404645-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

KIF2C Lentiviral Activation Particles (h) - sc-404645-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KIF2C Lentiviral Activation Particles (h2) - sc-404645-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

KIF2C siRNA (h) - sc-105596 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

KIF2C shRNA Plasmid (h) - sc-105596-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

KIF2C shRNA (h) Lentiviral Particles - sc-105596-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

KIF2C RNAi - H00011004-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

KIF2C RNAi - H00011004-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU046211 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11198 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11198 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12200 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr12200

KIF2C siRNA (Human) - CRH7514 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human KIF2C (NM_006845.3) - SHH325271 from Creative biogene Category siRNA Species Reactivities Human

KIF2C shRNA Plasmid (Human) - CHH7514 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

KIF2C miRNA 3'UTR clone - MiUTR1H-05312 from Creative biogene Species Reactivities Human

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