| Gene Symbol |
ISG20
|
| Entrez Gene |
3669
|
| Alt Symbol |
CD25, HEM45
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon stimulated exonuclease gene 20kDa
|
| Other Description |
estrogen-regulated transcript 45 protein|interferon-stimulated gene 20 kDa protein|promyelocytic leukemia nuclear body-associated protein ISG20
|
| Swissprots |
Q96AZ6 O00586 O00441
|
| Accessions |
EAX02013 EAX02014 EAX02015 EAX02016 Q96AZ6 AB209639 BAD92876 AK122793 AK307769 AV737297 BC007922 AAH07922 BC016341 AAH16341 BG759382 BI838264 BM691295 BT006952 AAP35598 BX339191 CN265233 CR456942 CAG33223 U88964 AAB53416 X89773 CAA61915 XM_005254899 XP_005254956 XM_006720488 XP_006720551 XM_011521521 XP_011519823 NM_001303233 NP_001290162 NM_001303234 NP_001290163 NM_001303235 NP_001290164 NM_001303236 NP_001290165 NM_001303237 NP_001290166 NM_002201 NP_002192 NR_130134
|
| Function |
Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. {ECO:0000269|PubMed:11401564, ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969, ECO:0000269|PubMed:21036379}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
|
| Tissue Specificity |
Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. {ECO:0000269|PubMed:9235947, ECO:0000269|PubMed:9569007}.
|