| Gene Symbol |
TRIM33
|
| Entrez Gene |
51592
|
| Alt Symbol |
ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 33
|
| Other Description |
E3 ubiquitin-protein ligase TRIM33|RET-fused gene 7 protein|TIF1-gamma|ectodermin homolog|protein Rfg7|transcriptional intermediary factor 1 gamma|tripartite motif-containing 33
|
| Swissprots |
Q9C017 Q5TG74 Q9UPN9 Q9UJ79 Q5TG72 O95855 Q5TG73
|
| Accessions |
EAW56599 EAW56600 EAW56601 Q9UPN9 AB029036 BAA83065 AB075517 AF119043 AAD17259 AF220136 AAG53509 AF220137 AAG53510 AJ132948 CAB55313 AK021491 BAB13834 AK023434 BAG51192 AK057487 AK301997 BAG63401 AL080216 CN267696 XM_005270936 XP_005270993 XM_005270937 XP_005270994 XM_011541568 XP_011539870 NM_015906 NP_056990 NM_033020 NP_148980
|
| Function |
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. Note=In discrete nuclear dots resembling nuclear bodies. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.
|