TRIM33

Gene Symbol	TRIM33
Entrez Gene	51592
Alt Symbol	ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 33
Other Description	E3 ubiquitin-protein ligase TRIM33|RET-fused gene 7 protein|TIF1-gamma|ectodermin homolog|protein Rfg7|transcriptional intermediary factor 1 gamma|tripartite motif-containing 33
Swissprots	Q9C017 Q5TG74 Q9UPN9 Q9UJ79 Q5TG72 O95855 Q5TG73
Accessions	EAW56599 EAW56600 EAW56601 Q9UPN9 AB029036 BAA83065 AB075517 AF119043 AAD17259 AF220136 AAG53509 AF220137 AAG53510 AJ132948 CAB55313 AK021491 BAB13834 AK023434 BAG51192 AK057487 AK301997 BAG63401 AL080216 CN267696 XM_005270936 XP_005270993 XM_005270937 XP_005270994 XM_011541568 XP_011539870 NM_015906 NP_056990 NM_033020 NP_148980
Function	Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. Note=In discrete nuclear dots resembling nuclear bodies. {ECO:0000250}.
Tissue Specificity	Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TIF1 gamma peptide - ab47108 from Abcam Category Peptide

Human TIF1 gamma protein fragment - ab153358 from Abcam Category Protein Source Wheat germ Species Human

TRIM33 / TIF1-Gamma Antibody Blocking Peptide - LS-E1397 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM33 / TIF1-Gamma Antibody Blocking Peptide - LS-E2585 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM33 / TIF1-Gamma Antibody Blocking Peptide - LS-E14145 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM33 / TIF1-Gamma Antibody Blocking Peptide - LS-E31449 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TIF1 gamma Protein - H00051592-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRIM33-Antibody-C-term-Blocking-peptide - BP12056b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRIM33-Antibody-C-term-Blocking-peptide - BP13643b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TRIM33 protein - orb169474 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source Sf9 Insect Cells. Species Human

TIF1-gamma / TRIM33 - H00051592-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TIF1-gamma / TRIM33 - H00051592-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRIM33 Peptide - 7385P from ProSci Category Peptide Species Human

Recombinant TRIM33 (959-1069) protein - 31367 from ActiveMotif Category Protein Prices $395.00 Sizes 100 µg Source E. coli Species Human

Recombinant Human TRIM33, His&FLAG-tagged - TRIM33-83H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human E3 ubiquitin-protein ligase TRIM33(TRIM33) ,partial - CSB-YP891796HU CSB-EP891796HU CSB-BP891796HU CSB-MP891796HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRIM33 (human) - pro90029 from Covalab Category Protein Source SF9 insect cells Species Human

Tripartite Motif Containing 33 Protein (Recombinant) - abx262628 from Abbexa Category Protein

TIF1-gamma / TRIM33 (transcript variant a) - TP312497 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TIF1-gamma / TRIM33 (full length, C-term DDK tag, transcript variant a) - TP710251 from Acris Antibodies Category Protein Prices $399.00 Sizes 20 µg Source SF9 cells Species Human

Recombinant Human TRIM33 Protein, GST-tagged - TRIM33-227H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human TRIM33 Protein, His-tagged - TRIM33-228H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human TRIM33 Protein, GST-tagged - TRIM33-229H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human TRIM33 Protein, His-tagged - TRIM33-230H from Creative Biomart Category Protein Source E. coli Species Human

TIF1 gamma Recombinant Protein Antigen - NBP1-83747PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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