TRIM33

Gene Symbol	TRIM33
Entrez Gene	51592
Alt Symbol	ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 33
Other Description	E3 ubiquitin-protein ligase TRIM33|RET-fused gene 7 protein|TIF1-gamma|ectodermin homolog|protein Rfg7|transcriptional intermediary factor 1 gamma|tripartite motif-containing 33
Swissprots	Q9C017 Q5TG74 Q9UPN9 Q9UJ79 Q5TG72 O95855 Q5TG73
Accessions	EAW56599 EAW56600 EAW56601 Q9UPN9 AB029036 BAA83065 AB075517 AF119043 AAD17259 AF220136 AAG53509 AF220137 AAG53510 AJ132948 CAB55313 AK021491 BAB13834 AK023434 BAG51192 AK057487 AK301997 BAG63401 AL080216 CN267696 XM_005270936 XP_005270993 XM_005270937 XP_005270994 XM_011541568 XP_011539870 NM_015906 NP_056990 NM_033020 NP_148980
Function	Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. Note=In discrete nuclear dots resembling nuclear bodies. {ECO:0000250}.
Tissue Specificity	Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® TRIM33 siRNA II - 13503 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® TRIM33 siRNA I - 13487 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

TIF1γ CRISPR/Cas9 KO Plasmid (h) - sc-403230 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ HDR Plasmid (h) - sc-403230-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ Double Nickase Plasmid (h) - sc-403230-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ Double Nickase Plasmid (h2) - sc-403230-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ CRISPR Activation Plasmid (h) - sc-403230-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ CRISPR Activation Plasmid (h2) - sc-403230-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ Lentiviral Activation Particles (h) - sc-403230-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ Lentiviral Activation Particles (h2) - sc-403230-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ siRNA (h) - sc-63127 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIF1γ shRNA Plasmid (h) - sc-63127-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIF1γ shRNA (h) Lentiviral Particles - sc-63127-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIF1 gamma RNAi - H00051592-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU157121 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK2342 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2344 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2343 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN21971 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21971 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TRIM33 siRNA (Human) - CRH9847 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TIF1 gamma RNAi - H00051592-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TRIM33 - MBS8202294 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TIF1γ CRISPR/Cas9 KO Plasmid (h2) - sc-403230-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIF1γ HDR Plasmid (h2) - sc-403230-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Search more