Gene Symbol | NPBWR2 |
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Entrez Gene | 2832 |
Alt Symbol | GPR8 |
Species | Human |
Gene Type | protein-coding |
Description | neuropeptides B/W receptor 2 |
Other Description | G protein-coupled receptor 8|G-protein coupled receptor 8|neuropeptides B/W receptor type 2|opioid-somatostatin-like receptor 8 |
Swissprots | Q9H4K3 Q6NWQ6 P48146 |
Accessions | AAC50198 EAW75161 P48146 BC067481 AAH67481 BC067482 AAH67482 BC067483 AAH67483 HQ447590 ADQ32076 NM_005286 NP_005277 |
Function | Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes. {ECO:0000269|PubMed:12401809}. |
Top Pathways | Neuroactive ligand-receptor interaction |
GPR8 CRISPR/Cas9 KO Plasmid (h) - sc-409621 from Santa Cruz Biotechnology
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GPR8 HDR Plasmid (h) - sc-409621-HDR from Santa Cruz Biotechnology
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GPR8 Double Nickase Plasmid (h) - sc-409621-NIC from Santa Cruz Biotechnology
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GPR8 Double Nickase Plasmid (h2) - sc-409621-NIC-2 from Santa Cruz Biotechnology
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GPR8 CRISPR Activation Plasmid (h) - sc-409621-ACT from Santa Cruz Biotechnology
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GPR8 CRISPR Activation Plasmid (h2) - sc-409621-ACT-2 from Santa Cruz Biotechnology
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GPR8 Lentiviral Activation Particles (h) - sc-409621-LAC from Santa Cruz Biotechnology
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GPR8 Lentiviral Activation Particles (h2) - sc-409621-LAC-2 from Santa Cruz Biotechnology
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GPR8 siRNA (h) - sc-105410 from Santa Cruz Biotechnology
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GPR8 shRNA Plasmid (h) - sc-105410-SH from Santa Cruz Biotechnology
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GPR8 shRNA (h) Lentiviral Particles - sc-105410-V from Santa Cruz Biotechnology
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GPR8 RNAi - H00002832-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15441 from Sigma-Aldrich
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NPBWR2 siRNA (Human) - CRH1897 from Cohesion Biosciences
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shRNA set against Human NPBWR2 (NM_005286.2) - SHH354088 from Creative biogene
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Human NPBWR2 siRNA - orb262399 from Biorbyt
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NPBWR2 shRNA Plasmid (Human) - CHH1897 from Cohesion Biosciences
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NPBWR2 miRNA 3'UTR clone - MiUTR1H-06871 from Creative biogene
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