| Gene Symbol |
PYCR2
|
| Entrez Gene |
29920
|
| Alt Symbol |
P5CR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pyrroline-5-carboxylate reductase family, member 2
|
| Other Description |
P5C reductase 2|pyrroline 5-carboxylate reductase isoform|pyrroline-5-carboxylate reductase 2
|
| Swissprots |
Q9Y5J4 Q7Z515 A8K798 Q96C36
|
| Accessions |
EAW69761 EAW69762 EAW69763 EAW69764 EAW69765 Q96C36 AF087859 AAP97169 AF151351 AAD34611 AK001508 BAG50929 AK291913 BAF84602 AL834217 CAD38899 AW166558 BC014868 AAH14868 BC020553 AAH20553 BU538765 HQ447797 ADQ32281 HY044355 HY264354 NM_001271681 NP_001258610 NM_013328 NP_037460
|
| Function |
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. {ECO:0000269|PubMed:2722838, ECO:0000269|PubMed:6894153}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:2722838}.
|
| Tissue Specificity |
Detected in erythrocytes (at protein level). {ECO:0000269|PubMed:2722838, ECO:0000269|PubMed:6894153}.
|
| Top Pathways |
Arginine and proline metabolism, Biosynthesis of amino acids
|