| Gene Symbol |
PI4K2B
|
| Entrez Gene |
55300
|
| Alt Symbol |
PI4KIIB, PIK42B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol 4-kinase type 2 beta
|
| Other Description |
PI4KII-BETA|phosphatidylinositol 4-kinase type 2-beta|phosphatidylinositol 4-kinase type II-beta|phosphatidylinositol 4-kinase type-II beta
|
| Swissprots |
Q8TCG2 Q9NUW2
|
| Accessions |
CAZ64455 EAW92836 Q8TCG2 AF411320 AAL04154 AK001967 BAA92006 AK023186 AK128622 BAG54701 AK296302 BAG59002 AY065990 AAL47580 AY091514 AAM12049 BC031014 BC051749 AAH51749 XM_005248174 XP_005248231 XM_005248175 XP_005248232 XM_011513855 XP_011512157 NM_018323 NP_060793
|
| Function |
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287}.
|
| Subcellular Location |
Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11923287}.
|
| Top Pathways |
Inositol phosphate metabolism, Phosphatidylinositol signaling system
|