PI4K2B

Gene Symbol PI4K2B
Entrez Gene 55300
Alt Symbol PI4KIIB, PIK42B
Species Human
Gene Type protein-coding
Description phosphatidylinositol 4-kinase type 2 beta
Other Description PI4KII-BETA|phosphatidylinositol 4-kinase type 2-beta|phosphatidylinositol 4-kinase type II-beta|phosphatidylinositol 4-kinase type-II beta
Swissprots Q8TCG2 Q9NUW2
Accessions CAZ64455 EAW92836 Q8TCG2 AF411320 AAL04154 AK001967 BAA92006 AK023186 AK128622 BAG54701 AK296302 BAG59002 AY065990 AAL47580 AY091514 AAM12049 BC031014 BC051749 AAH51749 XM_005248174 XP_005248231 XM_005248175 XP_005248232 XM_011513855 XP_011512157 NM_018323 NP_060793
Function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287}.
Subcellular Location Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11923287}.
Top Pathways Inositol phosphate metabolism, Phosphatidylinositol signaling system

PI 4-kinase II β (C-24) - sc-130232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PI 4-kinase II α (N-24):sc-130232. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.

Anti-PI 4 Kinase type 2 beta antibody - ab37812 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PI 4 Kinase type 2 beta antibody (ab37812) at 1/100 dilution + HL-60 cell lysate

Anti-PI 4 Kinase type 2 beta antibody - C-terminal - ab71823 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PI 4 Kinase type 2 beta antibody - C-terminal (ab71823) at 1/100 dilutionLane 1 : mouse brain lysateLane 2 : Saos2 cell lysateLysates/proteins at 12.5 µg per lane.SecondaryHRP-anti-rabbit

Anti-PI4K2B Antibody (C-Terminus, AP) - LS-C245338 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (C-Terminus, APC) - LS-C245339 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (N-Terminus, AP) - LS-C245344 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (C-Terminus, PE) - LS-C245343 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (C-Terminus, FITC) - LS-C245341 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (C-Terminus, Biotin) - LS-C245340 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (N-Terminus, APC) - LS-C245345 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (N-Terminus, Biotin) - LS-C245346 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (N-Terminus, FITC) - LS-C245347 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (N-Terminus, PE) - LS-C245349 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (C-Terminus, Azide-free, HRP) - LS-C247763 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (N-Terminus) - LS-C328245 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (N-Terminus, Azide-free, HRP) - LS-C247764 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (C-Terminus) - LS-C328246 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PI4K2B Antibody (aa90-139) - LS-C135432 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PI4K2B antibody LS-C135432 Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml.

Anti-PI4K2B Antibody (aa143-192) - LS-C112000 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PI4K2B antibody LS-C112000 Western blot of 721_B cell lysate.

Anti-PI4K2B Antibody (aa305-336) - LS-C101108 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-PI4K2B Antibody (aa1-30) - LS-C101107 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with PI4K II beta antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

PI 4 Kinase type 2 beta Antibody - NBP1-87908 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PI 4 Kinase type 2 beta Antibody [NBP1-87908] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

PIP5K2B Antibody - NBP1-44261 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PIP5K2B Antibody [NBP1-44261] - Lane 1: Mouse Brain homogenate samples. Load: 10 ug per lane. Primary antibody: PIP5K2B antibody at 0.2ug/mL for overnight at 4C. Secondary antibody: IRDye800 rabbit secondary antibody at 1:40,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4C. Predicted/Observed size: 54 kDa for PIP5K2B. Other band(s): None.

PI 4 Kinase type 2 beta Antibody - NBP1-56547 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PI 4 Kinase type 2 beta Antibody [NBP1-56547] - 721_B cell lysate, concentration 0.2-1 ug/ml.

PI 4 Kinase type 2 beta Antibody - NBP1-32263 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PI 4 Kinase type 2 beta Antibody [NBP1-32263] - Sample(30 ug of whole cell lysate)A:293T7. 5% SDS PAGE, antibody diluted at 1:500.
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