PI4K2B

Gene Symbol PI4K2B
Entrez Gene 55300
Alt Symbol PI4KIIB, PIK42B
Species Human
Gene Type protein-coding
Description phosphatidylinositol 4-kinase type 2 beta
Other Description PI4KII-BETA|phosphatidylinositol 4-kinase type 2-beta|phosphatidylinositol 4-kinase type II-beta|phosphatidylinositol 4-kinase type-II beta
Swissprots Q8TCG2 Q9NUW2
Accessions CAZ64455 EAW92836 Q8TCG2 AF411320 AAL04154 AK001967 BAA92006 AK023186 AK128622 BAG54701 AK296302 BAG59002 AY065990 AAL47580 AY091514 AAM12049 BC031014 BC051749 AAH51749 XM_005248174 XP_005248231 XM_005248175 XP_005248232 XM_011513855 XP_011512157 NM_018323 NP_060793
Function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287}.
Subcellular Location Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11923287}.
Top Pathways Inositol phosphate metabolism, Phosphatidylinositol signaling system

PI 4-kinase II β siRNA (h) - sc-89203 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PI 4-kinase II β shRNA Plasmid (h) - sc-89203-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PI 4-kinase II β shRNA (h) Lentiviral Particles - sc-89203-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PI 4 Kinase type 2 beta RNAi - H00055300-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU016031 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1628 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1630 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1629 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN16768 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16768 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10610 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10610

PI4K2B siRNA (Human) - CRJ0639 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PI4K2B (NM_018323.3) - SHH375200 from Creative biogene

Category siRNA
Species Reactivities Human

Human PI4K2B siRNA - orb271140 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PI4K2B shRNA Plasmid (Human) - CHJ0639 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PI4K2B miRNA 3'UTR clone - MiUTR4H-TG06676 from Creative biogene

Species Reactivities Human
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