PI4K2B

Gene Symbol	PI4K2B
Entrez Gene	55300
Alt Symbol	PI4KIIB, PIK42B
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol 4-kinase type 2 beta
Other Description	PI4KII-BETA|phosphatidylinositol 4-kinase type 2-beta|phosphatidylinositol 4-kinase type II-beta|phosphatidylinositol 4-kinase type-II beta
Swissprots	Q8TCG2 Q9NUW2
Accessions	CAZ64455 EAW92836 Q8TCG2 AF411320 AAL04154 AK001967 BAA92006 AK023186 AK128622 BAG54701 AK296302 BAG59002 AY065990 AAL47580 AY091514 AAM12049 BC031014 BC051749 AAH51749 XM_005248174 XP_005248231 XM_005248175 XP_005248232 XM_011513855 XP_011512157 NM_018323 NP_060793
Function	Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287}.
Subcellular Location	Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11923287}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PI 4 Kinase type 2 beta full length protein - ab105202 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

PI4K2B Antibody Blocking Peptide - LS-E9441 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PI4K2B Antibody Blocking Peptide - LS-E9442 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PI4K2B Antibody Blocking Peptide - LS-E20875 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PI4K2B Antibody Blocking Peptide - LS-E20874 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PI 4 Kinase type 2 beta Peptide - P3018 from Novus Biologicals Category Peptide Species Human

PI 4 Kinase type 2 beta Peptide - P3017 from Novus Biologicals Category Peptide Species Human

PI-4-Kinase-type-2-beta-antibody-C-term-Blocking-peptide - BP8033b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI-4-Kinase-type-2-beta-antibody-N-term-Blocking-peptide - BP8033a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI4K2B Blocking Peptide - 33R-3999 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Pi4k2b Blocking Peptide - 33R-2323 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PI4K2B fusion protein - Ag7120 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human PI4K2B - PI4K2B-30363TH from Creative Biomart Category Protein Source Baculovirus infected sf9 cells

Recombinant Human PI4K2B, His-tagged - PI4K2B-1699H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PI4K2B, GST-tagged - PI4K2B-1076H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human PI4K2B (Active), GST-tagged - PI4K2B-1451H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human Phosphatidylinositol 4-kinase type 2-beta(PI4K2B) - CSB-YP819460HU CSB-EP819460HU CSB-BP819460HU CSB-MP819460HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PI4K2B - TP308238 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Phosphatidylinositol 4-kinase type 2-beta (PI4K2B), Recombinant Protein - MBS1380521 from MyBioSource Category Protein Prices $1,265.00, $1,265.00, $1,485.00, $1,485.00, $2,070.00, $2,070.00, $2,530.00, $2,530.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PI 4 Kinase type 2 beta Protein - NBP1-87908PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

PI4K2B Peptide, Human - M34GP11738H from Creative Peptides Category Peptide Source Synthetic. Species Human

PI4K2B , Recombinant Protein - MBS515577 from MyBioSource Category Protein Prices $315.00, $425.00 Sizes 5 µg, 10 µg Source Sf9 insect cells using baculovirus Species Human

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