NOTCH2

Gene Symbol	NOTCH2
Entrez Gene	4853
Alt Symbol	AGS2, HJCYS, hN2
Species	Human
Gene Type	protein-coding
Description	notch 2
Other Description	Notch homolog 2|neurogenic locus notch homolog protein 2
Swissprots	Q5T3X7 Q9H240 Q99734 Q04721
Accessions	AAB17664 CAH70182 EAW56718 EAW56719 Q04721 AF308601 AAA36377 AF315356 AAG37073 AK027869 BAB55419 AK307843 AL049386 AL133036 CAB61366 BC071562 AAH71562 BG718124 DB290699 GQ231534 ADB12482 U77493 AAB19224 XM_005270901 XP_005270958 XM_011541519 XP_011539821 XM_011541520 XP_011539822 NM_001200001 NP_001186930 NM_024408 NP_077719
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. {ECO:0000269|PubMed:21378985}.
Top Pathways	Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NOTCH2 ELISA Kit (Sandwich ELISA) - LS-F9191 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.781-50 ng/ml

Human NOTCH2 ELISA Kit (Sandwich ELISA) - LS-F12174 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.781-50 ng/ml

Human Notch Homolog 2 ELISA Kit - abx152540 from Abbexa Category ELISA Kit Sensitivity 0.32 ng/ml Range 0.781 ng/ml - 50 ng/ml

Neurogenic locus notch homolog protein 2, NOTCH2, Human, ELISA Kit - E2420h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Notch Homolog 2, ELISA Kit - MBS100866 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS105509 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS096068 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS104291 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS054633 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS047479 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS056190 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS062084 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS099737 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS055194 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS076718 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS052143 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS081588 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS059574 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS105415 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS047822 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS089297 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS080600 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS053737 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS074224 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch Homolog 2, ELISA Kit - MBS078333 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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