NOTCH2

Gene Symbol NOTCH2
Entrez Gene 4853
Alt Symbol AGS2, HJCYS, hN2
Species Human
Gene Type protein-coding
Description notch 2
Other Description Notch homolog 2|neurogenic locus notch homolog protein 2
Swissprots Q5T3X7 Q9H240 Q99734 Q04721
Accessions AAB17664 CAH70182 EAW56718 EAW56719 Q04721 AF308601 AAA36377 AF315356 AAG37073 AK027869 BAB55419 AK307843 AL049386 AL133036 CAB61366 BC071562 AAH71562 BG718124 DB290699 GQ231534 ADB12482 U77493 AAB19224 XM_005270901 XP_005270958 XM_011541519 XP_011539821 XM_011541520 XP_011539822 NM_001200001 NP_001186930 NM_024408 NP_077719
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. {ECO:0000269|PubMed:21378985}.
Top Pathways Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

Notch 2 CRISPR/Cas9 KO Plasmid (h) - sc-401323 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 2 HDR Plasmid (h) - sc-401323-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 2 Double Nickase Plasmid (h) - sc-401323-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 2 Double Nickase Plasmid (h2) - sc-401323-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 2 CRISPR Activation Plasmid (h) - sc-401323-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 2 CRISPR Activation Plasmid (h2) - sc-401323-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 2 Lentiviral Activation Particles (h) - sc-401323-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 2 Lentiviral Activation Particles (h2) - sc-401323-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 2 siRNA (h) - sc-40135 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Notch 2 shRNA Plasmid (h) - sc-40135-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Notch 2 shRNA (h) Lentiviral Particles - sc-40135-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN1463 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1462 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1462 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1463 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NOTCH2 siRNA (Human) - CRH3225 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Notch-2 RNAi - H00004853-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Human NOTCH2 siRNA - orb263727 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NOTCH2 shRNA Plasmid (Human) - CHH3225 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NOTCH2 miRNA 3'UTR clone - MiUTR4H-TG11861 from Creative biogene

Species Reactivities Human
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