| Gene Symbol |
NOTCH2
|
| Entrez Gene |
4853
|
| Alt Symbol |
AGS2, HJCYS, hN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
notch 2
|
| Other Description |
Notch homolog 2|neurogenic locus notch homolog protein 2
|
| Swissprots |
Q5T3X7 Q9H240 Q99734 Q04721
|
| Accessions |
AAB17664 CAH70182 EAW56718 EAW56719 Q04721 AF308601 AAA36377 AF315356 AAG37073 AK027869 BAB55419 AK307843 AL049386 AL133036 CAB61366 BC071562 AAH71562 BG718124 DB290699 GQ231534 ADB12482 U77493 AAB19224 XM_005270901 XP_005270958 XM_011541519 XP_011539821 XM_011541520 XP_011539822 NM_001200001 NP_001186930 NM_024408 NP_077719
|
| Function |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. {ECO:0000269|PubMed:21378985}.
|
| Top Pathways |
Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation
|