NOTCH2

Gene Symbol	NOTCH2
Entrez Gene	4853
Alt Symbol	AGS2, HJCYS, hN2
Species	Human
Gene Type	protein-coding
Description	notch 2
Other Description	Notch homolog 2|neurogenic locus notch homolog protein 2
Swissprots	Q5T3X7 Q9H240 Q99734 Q04721
Accessions	AAB17664 CAH70182 EAW56718 EAW56719 Q04721 AF308601 AAA36377 AF315356 AAG37073 AK027869 BAB55419 AK307843 AL049386 AL133036 CAB61366 BC071562 AAH71562 BG718124 DB290699 GQ231534 ADB12482 U77493 AAB19224 XM_005270901 XP_005270958 XM_011541519 XP_011539821 XM_011541520 XP_011539822 NM_001200001 NP_001186930 NM_024408 NP_077719
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. {ECO:0000269|PubMed:21378985}.
Top Pathways	Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Notch2 protein fragment - ab114827 from Abcam Category Protein Source Wheat germ Species Human

NOTCH2 Antibody Blocking Peptide - LS-E11504 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOTCH2 Antibody Blocking Peptide - LS-E25998 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Notch-2 Protein - H00004853-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Notch-2 Peptide - NBP1-96994 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

NOTCH2 blocking peptide - GTX89477-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Recombinant Human Notch-2 Fc Chimera, CF - 3735-NT-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

NOTCH2 peptide - orb217684 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

NOTCH2 Blocking Peptide - abx063014 from Abbexa Category Peptide Species Human, Rat

NOTCH2 Blocking Peptide - abx063015 from Abbexa Category Peptide Species Human, Mouse, Rat

Notch 2 Peptide - AC21-0826-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NOTCH2 - H00004853-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NOTCH2 - H00004853-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NOTCH2 control peptide - AP09066CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

NOTCH2 Peptide - 45-977P from ProSci Category Peptide

Recombinant Human NOTCH2 - NOTCH2-29660TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Notch Homolog 2 (NOTCH2) - RPL148Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

NOTCH 2 (Human specific) Peptide - 000-000-408 from Rockland Immunochemicals Inc Category Peptide Prices $98.00 Sizes 50 µg Species Human

NOTCH2 Blocking Peptide - CBP1820 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Rat

NOTCH2 Blocking Peptide - CBP1821 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Cleaved-Notch 2 (D1733) Peptide - BS7015P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Cleaved-Notch 2 (A1734) Peptide - BS7043P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Notch2 - pro10365 from Covalab Category Protein Source CHO cells Species Mouse

Recombinant Human Neurogenic locus notch homolog protein 2(NOTCH2) ,partial - CSB-YP015950HU CSB-EP015950HU CSB-BP015950HU CSB-MP015950HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Notch-2 Fc Chimera Protein, CF - 3735-NT from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Human Notch-2 (Leu26 - Gln530) Accession # Q04721 IEGRMD Human IgG 1 (Pro100 - Lys330) N-terminus C-terminus Species Human

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