| Gene Symbol |
ESRP2
|
| Entrez Gene |
80004
|
| Alt Symbol |
RBM35B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
epithelial splicing regulatory protein 2
|
| Other Description |
RNA binding motif protein 35A|RNA binding motif protein 35B|RNA-binding motif protein 35B|RNA-binding protein 35B
|
| Swissprots |
Q9H6I4 Q9H6T0 Q8N6H8 Q8WZ15
|
| Accessions |
EAW83214 EAW83215 EAW83216 Q9H6T0 AF289577 AAL55761 AK025571 BAB15173 AK025901 BAB15275 BC030146 AAH30146 BC052309 BC069241 BG721782 BU934976 BU943912 LN680438 CEJ95641 LN680439 CEJ95642 T36047 XM_005256153 XP_005256210 XM_006721273 XP_006721336 XM_011523338 XP_011521640 NM_024939 NP_079215
|
| Function |
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19285943}.
|
| Tissue Specificity |
Epithelial cell-specific. {ECO:0000269|PubMed:19285943}.
|
![Western Blot: ESRP2 Overexpression Lysate (Adult Normal) [NBL1-15209] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ESRP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6773_ESRP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15209-img0002.jpg)