Gene Symbol | ESRP2 |
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Entrez Gene | 80004 |
Alt Symbol | RBM35B |
Species | Human |
Gene Type | protein-coding |
Description | epithelial splicing regulatory protein 2 |
Other Description | RNA binding motif protein 35A|RNA binding motif protein 35B|RNA-binding motif protein 35B|RNA-binding protein 35B |
Swissprots | Q9H6I4 Q9H6T0 Q8N6H8 Q8WZ15 |
Accessions | EAW83214 EAW83215 EAW83216 Q9H6T0 AF289577 AAL55761 AK025571 BAB15173 AK025901 BAB15275 BC030146 AAH30146 BC052309 BC069241 BG721782 BU934976 BU943912 LN680438 CEJ95641 LN680439 CEJ95642 T36047 XM_005256153 XP_005256210 XM_006721273 XP_006721336 XM_011523338 XP_011521640 NM_024939 NP_079215 |
Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19285943}. |
Tissue Specificity | Epithelial cell-specific. {ECO:0000269|PubMed:19285943}. |
RBM35B CRISPR/Cas9 KO Plasmid (h) - sc-408008 from Santa Cruz Biotechnology
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RBM35B HDR Plasmid (h) - sc-408008-HDR from Santa Cruz Biotechnology
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RBM35B Double Nickase Plasmid (h) - sc-408008-NIC from Santa Cruz Biotechnology
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RBM35B Double Nickase Plasmid (h2) - sc-408008-NIC-2 from Santa Cruz Biotechnology
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RBM35B CRISPR Activation Plasmid (h) - sc-408008-ACT from Santa Cruz Biotechnology
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RBM35B CRISPR Activation Plasmid (h2) - sc-408008-ACT-2 from Santa Cruz Biotechnology
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RBM35B Lentiviral Activation Particles (h) - sc-408008-LAC from Santa Cruz Biotechnology
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RBM35B Lentiviral Activation Particles (h2) - sc-408008-LAC-2 from Santa Cruz Biotechnology
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RBM35B siRNA (h) - sc-93408 from Santa Cruz Biotechnology
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RBM35B shRNA Plasmid (h) - sc-93408-SH from Santa Cruz Biotechnology
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RBM35B shRNA (h) Lentiviral Particles - sc-93408-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU120821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7993 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7993 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12733 from Sigma-Aldrich
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ESRP2 siRNA (Human) - CRJ2717 from Cohesion Biosciences
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ESRP2 RNAi - H00080004-R01 from Novus Biologicals
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ESRP2 - MBS8203280 from MyBioSource
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shRNA set against Human ESRP2 (NM_024939.2) - SHH287437 from Creative biogene
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shRNA set against Human RBM35B(NM_024939.2) - SHR169242 from Creative biogene
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Human ESRP2 siRNA - orb273218 from Biorbyt
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ESRP2 shRNA Plasmid (Human) - CHJ2717 from Cohesion Biosciences
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ESRP2 miRNA 3'UTR clone - MiUTR1H-08683 from Creative biogene
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