Gene Symbol | ESRP2 |
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Entrez Gene | 80004 |
Alt Symbol | RBM35B |
Species | Human |
Gene Type | protein-coding |
Description | epithelial splicing regulatory protein 2 |
Other Description | RNA binding motif protein 35A|RNA binding motif protein 35B|RNA-binding motif protein 35B|RNA-binding protein 35B |
Swissprots | Q9H6I4 Q9H6T0 Q8N6H8 Q8WZ15 |
Accessions | EAW83214 EAW83215 EAW83216 Q9H6T0 AF289577 AAL55761 AK025571 BAB15173 AK025901 BAB15275 BC030146 AAH30146 BC052309 BC069241 BG721782 BU934976 BU943912 LN680438 CEJ95641 LN680439 CEJ95642 T36047 XM_005256153 XP_005256210 XM_006721273 XP_006721336 XM_011523338 XP_011521640 NM_024939 NP_079215 |
Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19285943}. |
Tissue Specificity | Epithelial cell-specific. {ECO:0000269|PubMed:19285943}. |
Human ESRP2 full length protein - ab164177 from Abcam
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ESRP2 / RBM35B Antibody Blocking Peptide - LS-E15051 from LifeSpan Bioscience
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ESRP2 / RBM35B Antibody Blocking Peptide - LS-E31079 from LifeSpan Bioscience
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ESRP2 / RBM35B Antibody Blocking Peptide - LS-E15645 from LifeSpan Bioscience
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ESRP2 / RBM35B Antibody Blocking Peptide - LS-E13606 from LifeSpan Bioscience
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ESRP2 / RBM35B Antibody Blocking Peptide - LS-E13471 from LifeSpan Bioscience
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Recombinant Human ESRP2 Protein - H00080004-P01 from Novus Biologicals
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ESRP2 Blocking Peptide - NBP1-76537PEP from Novus Biologicals
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Esrp2 Blocking Peptide - 33R-5174 from Fitzgerald
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RBM35B Blocking Peptide - 33R-1548 from Fitzgerald
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RBM35B Blocking Peptide - 33R-6217 from Fitzgerald
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ESRP2 / RBM35B - H00080004-P01 from Acris Antibodies
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ESRP2 / RBM35B - H00080004-P01-10 from Acris Antibodies
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ESRP2 / RBM35B control peptide - AP26108CP-N from Acris Antibodies
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RBM35B Peptide - 6187P from ProSci
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ESRP2 fusion protein - ag19306 from Proteintech Group
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ESRP2 fusion protein - ag19436 from Proteintech Group
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Recombinant Human Epithelial splicing regulatory protein 2(ESRP2) - CSB-YP007833HU CSB-EP007833HU CSB-BP007833HU CSB-MP007833HU from Cusabio
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ESRP2 / RBM35B - TP304916 from Acris Antibodies
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ESRP2 Recombinant Protein Antigen - NBP2-13972PEP from Novus Biologicals
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ESRP2 Peptide, Human - M34GP05085H from Creative Peptides
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ESRP2 Recombinant Protein Antigen - NBP2-58259PEP from Novus Biologicals
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Epithelial splicing regulatory protein 2 (ESRP2), Recombinant Protein - MBS1374868 from MyBioSource
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