| Gene Symbol |
DTX2
|
| Entrez Gene |
113878
|
| Alt Symbol |
RNF58
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
deltex 2, E3 ubiquitin ligase
|
| Other Description |
deltex homolog 2|deltex2|hDTX2|probable E3 ubiquitin-protein ligase DTX2|protein deltex-2|ring finger protein 58|zinc ion binding protein
|
| Swissprots |
Q9P200 Q86UW9 Q9H890 Q96H69 Q6XM88 Q6XM87
|
| Accessions |
AAP21881 AAS07525 EAW50382 Q86UW9 AB040961 BAA96052 AK023924 BAB14727 AK026252 AK293226 BAG56765 AY225124 AAP57518 AY225125 AAP57519 BC008856 AAH08856 BC013192 BC018555 AAH18555 BC026059 AAH26059 BC064535 AAH64535 BC093079 AAH93079 BP306192 DA003606 DA917716 DQ010329 AAY27263 DQ082728 AAZ06433 DQ082730 AAZ06435 DQ893264 ABM84190 DQ896593 ABM87592 XM_005250131 XP_005250188 XM_005250132 XP_005250189 XM_011515772 XP_011514074 XM_011515773 XP_011514075 XM_011515774 XP_011514076 XM_011515775 XP_011514077 XM_011515776 XP_011514078 XM_011515777 XP_011514079 NM_001102594 NP_001096064 NM_001102595 NP_001096065 NM_001102596 NP_001096066 NM_020892 NP_065943
|
| Function |
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11564735}. Nucleus {ECO:0000269|PubMed:11564735}. Note=Predominantly cytoplasmic. Partially nuclear.
|
| Top Pathways |
Notch signaling pathway
|